|
Variable
|
Differencea
|
P
b
|
Adjusted differencecweight loss added to the model
|
P
b
|
|---|
|
Anthropometric
| | | | |
|
Abdominal circumference (cm)
|
−0.4 (−2.4;1.6)
|
0.69
|
−0.9 (−3.2;1.5)
|
0.56
|
|
Systolic BP (mmHg)
|
−9.1 (−16.2;-1.9)
|
0.02
|
−13.0 (−25.4;-0.6)
|
0.04
|
|
Diastolic BP (mmHg)
|
−5.2 (−10.0;-0.3)
|
0.04
|
−4.9 (−10.7;0.9)
|
0.09
|
|
Characteristics of the MetS (n)
|
−1.1 (−1.9;-0.3)
|
0.01
|
−1.0 (−1.8;-0.1)
|
0.03
|
|
Glucose tolerance and insulin sensitivity
| | | |
|
Glucose fasting (mmol/l)
|
−0.1 (−0.5;0.3)
|
0.68
|
−0.0 (−0.5;0.5)
|
0.91
|
|
Insulin fasting (mU/l)
|
−2.0 (−5.0;1.1)
|
0.20
|
−1.4 (−5.1;2.3)
|
0.44
|
|
HOMAIR
|
−0.5 (−1.4;0.4)
|
0.28
|
−0.5 (−1.6;0.7)
|
0.41
|
|
AUC glucose (mmol/l x min)
|
−28 (−157;101)
|
0.66
|
−107 (−247; 33)
|
0.13
|
|
AUC insulin (mU/l x min)
|
−1 342 (−415; 3 099)
|
0.13
|
−484 (−2 503; 1 535)
|
0.63
|
|
TG:HDL-C (mol/mol)
|
−0.9 (−1.3;-0.5)
|
0.00
|
−0.7 (−1.1;-0.3)
|
0.00
|
|
Lipids
| | | | |
|
TC (mmol/l)
|
−0.5 (−1.0;-0.0)
|
0.04
|
−0.3 (−0.8;0.3)
|
0.35
|
|
HDL-C (mmol/l)
|
0.2 (0.0;0.3)
|
0.01
|
0.15 (0.01;0.29)
|
0.04
|
|
LDL-C (mmol/l)
|
−0.1 (−0.5;0.3)
|
0.56
|
−0.1 (−0.5;0.4)
|
0.75
|
|
TG (mmol/l)
|
−0.9 (−1.3;-0.5)
|
0.00
|
−0.7 (−1.0;-0.3)
|
0.00
|
|
TC:HDL-C (mol/mol)
|
−1.2 (−1.9;-0.4)
|
0.00
|
−1.1 (−2.0;-0.3)
|
0.01
|
|
Inflammation
| | | | |
|
hsCRP (mg/l)
|
0.1 (−2.2;2.3)
|
0.96
|
0.1 (−2.7;2.8)
|
0.95
|
|
TNFα (pg/ml)
|
−0.6 (−1.7;0.6)
|
0.32
|
−0.7 (−2.0;0.7)
|
0.31
|
|
Intestinal permeability
| | | | |
|
Lactulose:mannitol (mmol/mol)
|
−0.07 (−0.023;0.008)
|
0.35
|
−0.012 (−0.031;0.008)
|
0.24
|
|
Stress parameter
| | | | |
|
Diurnal cortisol slope
|
−0.08 (−0.36;0.20)
|
0.54
|
−0.10 (−0.44;0.25)
|
0.24
|
|
wakeup-bedtime
| | | | |
- Abbreviations: TG triglycerides, HDL-C HDL-cholesterol, TC total cholesterol, LDL-C LDL-cholesterol.
- Adjusted differences after the intervention between both diets without and with weight loss added to the model.
- aDifference = Palaeolithic-type diet – reference diet (with 95% CI).
- bP values between the two intervention groups after the intervention.
- cAdjusted difference = Palaeolithic-type diet – reference diet (with 95% CI), percentage weight loss added to the model as fixed effect.
