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Table 3 Stratified analyses for the CKD risk associated with APOA5 polymorphisms by BMI levels

From: Polymorphisms of genes involved in lipid metabolism and risk of chronic kidney disease in Japanese - cross-sectional data from the J-MICC study

Proportion of minor heterozygous plus homozygous (among subjects with all genotypes) CKD (+) CKD (-) OR* 95% CI* P interaction #
(n = 564) (n = 2,704)    
Genotype BMI N (%) N (%)    
APOA5 T-1131C        
(rs662799)         
  ≥ 30 15/16 (93.8) 54/95 (56.8) 12.39 1.55-99.09  
  < 30 328/548 (59.9) 1,453/2,609 (55.7) 1.21 0.999-1.47 0.028
APOA5 T1259C        
(rs2266788)         
  ≥ 30 13/16 (81.3) 50/95 (52.6) 3.68 0.97-13.93  
  < 30 269/548 (49.1) 1,217/2,609 (46.6) 1.14 0.95-1.38 0.079
  1. *aOR: adjusted odds ratio (adjusted for age and sex); 95% CI: 95% confidence interval.
  2. #OR for interaction =10.43 (95% CI: 1.29-84.19) for APOA5 rs662799, and 3.36 (95% CI: 0.87-13.01) for APOA5 rs2266788.