Figure 3
From: Pharmacogenomic analysis of retinoic-acid induced dyslipidemia in congenic rat model
Network analysis of pharmacogenetic interaction of RA. The figure represents the network with highest score (IPA, Ingenutiy Systems) derived using the set of transcripts showing significant STRAIN (SHR, SHR-Lx) * ATRA (STD, STD + RA) interaction. The genes with validated expression changes by real-time PCR are shown in green. After in silico analysis of direct and indirect connections of the genes present within the chromosome 8 differential segment in SHR-Lx to the members of this highest-scoring network, only the Zbtb16 gene (yellow) showed positive results.