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Table 2 Major triacylglycerol, cholesterol subfractions and free glycerol comparison between control and retinoic acid-fed SHR vs. SHR- Lx rats

From: Pharmacogenomic analysis of retinoic-acid induced dyslipidemia in congenic rat model

Trait (mg/dl)

Standard diet

Standard diet + ATRA

SHR

SHR-Lx

SHR

SHR-Lx

 

(n = 7)

(n = 7)

(n = 7)

(n = 8)

Triacylglycerol (TG)

Total TG

61.84 ± 4.50

46.33 ± 2.38a

69.87 ± 5.51

77.27 ± 4.66‡

Chylomicron TG

7.97 ± 0.83

3.66 ± 0.34a

8.47 ± 1.05

11.94 ± 0.67‡,b

VLDL-TG

37.27 ± 3.28

27.68 ± 2.05

42.67 ± 4.11

44.83 ± 4.37†,a

LDL-TG

12.29 ± 0.47

12.04 ± 0.39

14.07 ± 0.85

14.28 ± 1.12

HDL-TG

4.32 ± 0.13

2.95 ± 0.12

4.66 ± 0.36

6.23 ± 0.99‡

Cholesterol (C)

Total C

45.92 ± 1.57

38.46 ± 1.55c

42.52 ± 1.34

40.26 ± 0.78

Chylomicron C

0.63 ± 0.05

0.29 ± 0.02c

0.69 ± 0.07

1.18 ± 0.20 ‡,b

VLDL-C

3.26 ± 0.27

2.32 ± 0.10 a

3.70 ± 0.22

5.10 ± 0.46‡,b

LDL-C

11.26 ± 0.44

9.10 ± 0.31c

9.77 ± 0.37*

9.78 ± 0.39

HDL-C

30.77 ± 1.38

26.75 ± 1.37a

28.37 ± 1.20

24.20 ± 0.94a

Glycerol

1.07 ± 0.12

1.00 ± 0.06

1.24 ± 0.15

0.99 ± 0.02

  1. Data are shown as mean ± S.E.M. The significance levels are indicated as follows: a, b, c…p <0.05, 0.01 and 0.001, respectively for differences between SHR and SHR-Lx under conditions of a single diet; †, ‡… p <0.01 and 0.001, respectively, for RA effect within individual strain.