Figure 2

Renal function evaluation using creatinine clearance (A) plasma levels of urea (B) and proteinuria (C). The association of hypercholesterolemia and ovariectomy resulted in a marked renal dysfunction, as demonstrated by the reduced glomerular filtration rate and increased uremia and proteinuria. C57 Sham n = 10-12, C57 OVX n = 8-11, ApoE Sham n = 7-13, ApoE OVX n = 7-12. Values are means ± SEMs. ^#p < 0.05 and ^##p < 0.01 vs. respective control; &p < 0.05 vs. C57 sham; ^$p < 0.05 vs. all other groups. Two-way ANOVA followed by Tukey’s post hoc test.