Figure 3

Glomerular histological quantification of superoxide anion production (A) and lipid deposition (B). (A) Hypercholesterolemia resulted in elevated glomerular oxidative stress, which was exacerbated by the removal of endogenous female sex hormones. (B) As expected, lipid deposition was enhanced in ApoE groups, but it was not influenced by ovariectomy. C57 n = 4-7, ApoE n = 7-9. Values are means ± SEMs. ^##p < 0.01 vs. respective control; &p < 0.05 vs. C57 sham; **p < 0.01 vs. C57. Two-way ANOVA followed by Tukey’s post hoc test.