Relation of plasma PCSK9 levels to lipoprotein subfractions in patients with stable coronary artery disease

Table 5 Independent associations of the PCSK9 levels with the lipid profile and lipoprotein subfractions across gender

Variables	Multivariable linear regression analysis
	Male		Female
	Coefficients	P-value	Coefficients	P-value
TC (mg/dl)	0.289	0.000	0.042	0.733
TG (mg/dl)	0.148	0.031	-0.160	0.183
Non-HDL-C (mg/dl)	0.264	0.000	0.033	0.787
Apo A-I (g/L)	0.223	0.001	0.050	0.683
Apo B (g/L)	0.269	0.000	0.146	0.233
LDL-C (mg/dl)	0.230	0.001	0.065	0.587
Large LDL-C (mg/dl)	-0.006	0.929	0.140	0.248
Intermediate LDL-C (mg/dl)	0.183	0.009	0.041	0.739
Small LDL-C (mg/dl)	0.240	0.001	-0.063	0.605
LDL score (% of sd-LDL)	0.177	0.015	-0.060	0.603
Mean LDL size (Å)	-0.174	0.015	0.030	0.806
HDL-C (mg/dl)	0.100	0.157	0.021	0.862
Large HDL-C (mg/dl)	-0.044	0.550	-0.074	0.502
Intermediate HDL-C (mg/dl)	0.087	0.253	0.043	0.730
Small HDL-C (mg/dl)	0.149	0.045	-0.172	0.166

The multivariable linear regression analysis was adjusted for age, BMI, hypertension, diabetes mellitus, current smoking and positive family history. The lipids and lipoprotein subfractions are the dependent variables.
TC: total cholesterol. TG: triglycerides. Non-HDL-C: non high-density lipoprotein cholesterol. ApoA-I: apolipoprotein A1. ApoB: apolipoprotein B. LDL-C: low-density lipoprotein-cholesterol. HDL-C: high-density lipoprotein cholesterol.

ISSN: 1476-511X