| Exam 1 (1999–2001) | Exam 2 (2002–2005) | Exam 3 (2005–2008) | Exam 4 (2008–2011) | p-value for trend |
---|---|---|---|---|---|
Male | Â | Â | Â | Â | Â |
  TC†| 5.21 (5.20-5.22) | 5.13 (5.12-5.15) | 5.00 (4.99-5.01) | 4.88 (4.87-5.00) | <0.001 |
  LDL-C†| 3.82 (3.81-3.83) | 3.73 (3.72-3.74) | 3.58 (3.57-3.59) | 3.43 (3.42-3.45) | <0.001 |
  HDL-C†| 0.95 (0.94-0.95) | 0.97 (0.96-0.98) | 1.013 (1.010-1.017) | 1.058 (1.055-1.062) | <0.001 |
  TG†| 2.11 (2.08-2.14) | 1.96 (1.92-1.99) | 1.93 (1.90-1.96) | 1.94 (1.91-1.98) | 0.057 |
  Non-HDL-C†| 4.26 (4.25-4.28) | 4.15 (4.14-4.17) | 3.98 (3.97-4.0) | 3.82 (3.80-3.83) | <0.001 |
  TG/HDL | 2.43 (2.41-2.46) | 2.31 (2.3-2.34) | 2.15 (2.12-2.17) | 2.00 (1.97-2.03) | <0.001 |
  TC/HDL | 5.77 (5.75-5.8) | 5.52 (5.5-5.54) | 5.18 (5.16-5.2) | 4.84 (4.81-4.86) | <0.001 |
  FPG†| 5.35 (5.32-5.37) | 5.54 (5.51-5.57)) | 5.62(5.59-5.64) | 5.73 (5.71-5.75) | <0.001 |
  BMI (kg/m2) | 25.92 (25.87-25.97) | 26.3 (26.23-26.35) | 26.78 (26.72-26.84) | 27.45 (27.4-27.51) | <0.001 |
Female | Â | Â | Â | Â | Â |
  TC†| 5.42 (5.39-5.43) | 5.37 (5.34-5.4) | 5.18 (5.16-5.20) | 5.07 (5.04-5.06) | <0.001 |
  LDL-C†| 3.90 (3.88-3.92) | 3.81 (3.79-3.83) | 3.61 (3.59-3.63) | 3.46 (3.44-3.48) | <0.001 |
  HDL-C†| 1.103 (1.101-1.104) | 1.140 (1.130-1.142) | 1.039 (1.037-1.194) | 1.246 (1.241-1.251) | <0.001 |
  TG†| 1.88 (1.86-1.91) | 1.80 (1.77-1.83) | 1.71 (1.68-1.73) | 1.74 (1.71-1.77) | <0.001 |
  Non-HDL-C†| 4.31 (4.29-4.33) | 4.22 (4.20-4.24) | 3.98 (3.96-4.00) | 3.82 (3.80-3.85) | <0.001 |
  TG/HDL-C | 1.88 (1.87-1.90) | 1.82 (1.80-1.84) | 1.63 (1.61-1.65) | 1.54 (1.51-1.57) | <0.001 |
  TC/HDL-C | 5.20 (5.17-5.21) | 4.95 (4.93-4.98) | 4.57 (4.56-4.60) | 4.28 (4.25-4.32) | <0.001 |
  FPG†| 5.47 (5.44-5.49) | 5.63 (5.60-5.66) | 5.63 (5.61-5.66) | 5.78 (5.75-5.81) | 0.37 |
  BMI (kg/m2) | 27.76 (27.7-27.82) | 28.64 (28.56-28.71) | 29.11 (29.05-29.18) | 30.02 (29.95-30.10) | <0.001 |