Coenzyme Q10 supplementation improves metabolic parameters, liver function and mitochondrial respiration in rats with high doses of atorvastatin and a cholesterol-rich diet

Table 2 Effect of a cholesterol-rich diet and atorvastatin with or without coenzyme Q₁₀ supplementation on transaminases

	CD	CD + ATV₂	HD	HD + ATV₁	HD + ATV₂	HD + ATV₃
		(0.56 mg/day)		(0.2 mg/day)	(0.56 mg/day)	(1.42 mg/day)
ALT
Without CoQ₁₀	67.1 ± 9.19	56.32 ± 0.8^a	84.8 ± 7.9^a	128.0 ± 8.9^b	60.9 ± 2.5^b	57.10 ± 5.11^b
With CoQ₁₀	49.05 ± 5.58	48.33 ± 3.86¹	102.6 ± 9.9¹	94.10 ± 18.40	44.15 ± 6.45^b,1	56.8 ± 0.75^b
AST
Without CoQ₁₀	165.2 ± 9.7	209.2 ± 10.83^a	223.6 ± 14.27^a	273.7 ± 6.98^b	224.6 ± 8.8	196.0 ± 7.31^b
With CoQ₁₀	227.8 ± 1.98	164.0 ± 1.90^a,1	313.3 ± 4.87^a,1	239.9 ± 9.05^b,1	261.4 ± 11.20^b,1	247.5 ± 15.45^b,1

CD, control diet; CD + ATV₂, CD + atorvastatin 0.56 mg/day; HD, hypercholesterolemic diet; HD + ATV₁, 0.2 mg/day; HD + ATV₂ 0.56 mg/day; HD + ATV₃ 1.42 mg/day, Coenzyme Q₁₀, 0.57 mg/day; Data are expressed as mean ± S.E.M.; n = 8. One-way analysis of variance (ANOVA) (groups CD, CD + ATV₂, HD, HD + ATV₁, HD + ATV₂, HD + ATV₃) accompanied by the Student-Newman-Keuls test and differences between the groups were determined by the Student's t test (Without CoQ10 vs With CoQ10) (p < 0.05). ^aStatistically different from either CD or CD + CoQ₁₀ (p < 0.05); ^bstatistically different from either HD or HD + CoQ₁₀ (p < 0.05); ¹statistically different from the same group without CoQ₁₀.

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