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Table 3 Effect of CoQ 10 supplementation on liver cholesterol and triacylglycerols of rats with a cholesterol-rich diet and atorvastatin

From: Coenzyme Q10 supplementation improves metabolic parameters, liver function and mitochondrial respiration in rats with high doses of atorvastatin and a cholesterol-rich diet

 

CD

CD + ATV2

HD

HD + ATV1

HD + ATV2

HD + ATV3

  

(0.56 mg/day)

 

(0.2 mg/day)

(0.56 mg/day)

(1.42 mg/day)

TC

      

Without CoQ10

2.71 ± 0.86

2.77 ± 0.33

12.43 ± 2.84a

7.80 ± 1.73b

8.71 ± 0.62b

7.38 ± 1.15b

With CoQ10

2.30 ± 0.75

1.87 ± 0.34a,1

6.42 ± 0.86a,1

2.42 ± 0.47b,1

2.25 ± 0.46b,1

3.30 ± 0.75b,1

TAG

      

Without CoQ10

5.58 ± 0.88

7.53 ± 0.45a

10.66 ± 0.33a

9.73 ± 1.95

9.70 ± 1.50

6.31 ± 2.23b

With CoQ10

4.30 ± 0.551

6.24 ± 1.16a,1

10.70 ± 0.32a

3.73 ± 0.60b,1

2.81 ± 0.11b, 1

6.47 ± 0.20b

  1. CD, control diet; CD + ATV2, CD + atorvastatin 0.56 mg/day; HD, hypercholesterolemic diet; HD + ATV1, 0.2 mg/day; HD + ATV2 0.56 mg/day; HD + ATV3 1.42 mg/day, Coenzyme Q10, 0.57 mg/day; Data are expressed as mean ± S.E.M.; n = 8. One-way analysis of variance (ANOVA) (groups CD, CD + ATV2, HD, HD + ATV1, HD + ATV2, HD + ATV3) accompanied by the Student-Newman-Keuls test and differences between the groups were determined by the Student's t test (Without CoQ10 vs With CoQ10) (p < 0.05). aStatistically different from either CD or CD + CoQ10 (p < 0.05); bstatistically different from either HD or HD + CoQ10 (p < 0.05); 1statistically different from the same group without CoQ10.