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Figure 2 | Lipids in Health and Disease

Figure 2

From: miR-21 attenuates lipopolysaccharide-induced lipid accumulation and inflammatory response: potential role in cerebrovascular disease

Figure 2

Effect of miR-21 on lipid-laden foam cell formation in LPS-stimulated macrophages. To investigate the function of miR-21 on LPS-induced lipid accumulation, cells were respectively transfected with miR-21 mimics, scrambled control microRNA, anti-miR-210 inhibitor and anti-microRNA control inhibitor for 6 h. (A) Overexpression of miR-21 in miR-21 transfected cells. *P < 0.05 versus control microRNA group. (B) Down-regulation of miR-21 in macrophages. *P < 0.05 versus anti-microRNA control inhibitor group. (C-D) After exposure to ox-LDL (μg/ml) for 24 h, the ratio of CE/TC and foam cell formation was assessed by HPLC assay (C) and Oil red O staining (D). *P < 0.05.

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Lipids in Health and Disease

ISSN: 1476-511X