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Figure 4 | Lipids in Health and Disease

Figure 4

From: miR-21 attenuates lipopolysaccharide-induced lipid accumulation and inflammatory response: potential role in cerebrovascular disease

Figure 4

miR-21 regulated the secretion of inflammatory cytokines in LPS-induced macrophages. (A) Following transfection with miR-21, levels of IL-6 and IL-10 was detected by ELISA assay. *P < 0.05 versus LPS-untreated group. #P < 0.05 versus LPS plus miR-con group. (B-C) The effect of miR-21 silencing on IL-6 and IL-10 levels in macrophages exposed to 100 ng/ml LPS. (D) Cells were pretreatment with anti-TLR4 antibody (10 μg/ml) or 30 μM NF-κB inhibitor PDTC for 4 h, and then LPS-induced IL-6 and IL-10 levels were detected in anti-miR-21 inhibitor-transfected cells. *P < 0.05.

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Lipids in Health and Disease

ISSN: 1476-511X