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Table 4 Categorization of the parameters in the different tissues

From: Eicosapentaenoic acid/docosahexaenoic acid 1:1 ratio improves histological alterations in obese rats with metabolic syndrome

Meaning

Grade

Meaning

Grade

Meaning

Grade

Aorta

 

Liver

 

Kidney

 

Thickness of wall (μm)

 

Steatosis

 

Glomerulosclerosis

 

Lumen perimeter (mm)

 

  < 5%

0

  Absence

0

Lumen area (mm2)

 

  5-33%

1

  Presence

1

Density of elastic bands

 

  33-66%

2

Atrophy

 

  Yes

1

  > 66%

3

  Absence

0

  No

2

Localization of steatosis

 

  Light

1

Wrinkling of elastic layers

  Centrilobular

0

  Middle

2

  Yes

1

  Periportal

1

  Marked

3

  Heterogeneous

2

  No zonal

2

Thyroidization

 

  No

3

  

  Absence

0

Nuclear hypertrophy

 

Lobular inflammation

 

  Light

1

  No

1

  No

0

  Middle

2

  Heterogeneous

2

  < 2 focus

1

  Marked

3

  Yes

3

  2-4 focus

2

Fibrosis

 
  

  > 4 focus

3

  Absence

0

Adipose tissue

 

Portal inflammation

 

  Presence

1

Differently sized adipocytes

 

  No

0

Lipid depositions

 

  Yes

1

  Yes

1

  Absence

0

  No

0

Fibrosis

 

  Light

1

Macrophages

 

  No

0

  Moderate

2

  Presence

1

  Perisinusoidal or periportal

1

Inflammation

 

  Absence

0

  Fibrosis bridges

2

  Absence

0

Mast cells

 

  Cirrhosis

3

  Light

1

  Presence

1

Microgranuloma

 

  Moderate

2

  Absence

0

  Absence

0

  Marked

3

Inflammation

 

  Presence

1

  

  No

0

Lipogranuloma

   

  Light

1

  Absence

0

  

  Moderate

2

  Presence

1

  

  Marked

3

Macrophages

   
  

  Absence

0

  
  

  Presence

1

  
  1. Categorization of the parameters in the different tissues based on the literature: Park S and Park Y, 2009 [12]; Engler, et al., 2003 [13]; Muñoz, et al., 2009 [28]; Xu ZJ, et al.,2010 [29]; Dobrian, et al., 2003 [30].