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Table 4 Categorization of the parameters in the different tissues

From: Eicosapentaenoic acid/docosahexaenoic acid 1:1 ratio improves histological alterations in obese rats with metabolic syndrome

Meaning Grade Meaning Grade Meaning Grade
Aorta   Liver   Kidney  
Thickness of wall (μm)   Steatosis   Glomerulosclerosis  
Lumen perimeter (mm)     < 5% 0   Absence 0
Lumen area (mm2)     5-33% 1   Presence 1
Density of elastic bands     33-66% 2 Atrophy  
  Yes 1   > 66% 3   Absence 0
  No 2 Localization of steatosis     Light 1
Wrinkling of elastic layers   Centrilobular 0   Middle 2
  Yes 1   Periportal 1   Marked 3
  Heterogeneous 2   No zonal 2 Thyroidization  
  No 3      Absence 0
Nuclear hypertrophy   Lobular inflammation     Light 1
  No 1   No 0   Middle 2
  Heterogeneous 2   < 2 focus 1   Marked 3
  Yes 3   2-4 focus 2 Fibrosis  
     > 4 focus 3   Absence 0
Adipose tissue   Portal inflammation     Presence 1
Differently sized adipocytes     No 0 Lipid depositions  
  Yes 1   Yes 1   Absence 0
  No 0 Fibrosis     Light 1
Macrophages     No 0   Moderate 2
  Presence 1   Perisinusoidal or periportal 1 Inflammation  
  Absence 0   Fibrosis bridges 2   Absence 0
Mast cells     Cirrhosis 3   Light 1
  Presence 1 Microgranuloma     Moderate 2
  Absence 0   Absence 0   Marked 3
Inflammation     Presence 1   
  No 0 Lipogranuloma    
  Light 1   Absence 0   
  Moderate 2   Presence 1   
  Marked 3 Macrophages    
     Absence 0   
     Presence 1   
  1. Categorization of the parameters in the different tissues based on the literature: Park S and Park Y, 2009 [12]; Engler, et al., 2003 [13]; Muñoz, et al., 2009 [28]; Xu ZJ, et al.,2010 [29]; Dobrian, et al., 2003 [30].