Dietary pulp from Fructus Schisandra Chinensis supplementation reduces serum/hepatic lipid and hepatic glucose levels in mice fed a normal or high cholesterol/bile salt diet

Table 2 Effects of dietary supplementation with SAqFSC-P, PAqFSC-P, or bicyclol on hepatic index, protein and function in normal and hypercholesterolemic mice

Groups	Drug concentration (%, w/w)	Hepatic index (%)	Hepatic protein (g/g liver tissue)	Serum ALT activity (U/L)
*Normal mice*
Control ND	-	6.59 ± 0.10	0.138 ± 0.003	36.50 ± 3.61
SAqFSC-P/ND	1	6.76 ± 0.13	0.131 ± 0.003	27.60 ± 0.72^a
	9	6.91 ± 0.13	0.140 ± 0.004	30.33 ± 2.41
PAqFSC-P/ND	1	6.73 ± 0.11	0.146 ± 0.002^a	32.80 ± 1.63
	9	7.16 ± 0.17^b	0.155 ± 0.003^b	32.00 ± 1.81
Bicyclol/ND	0.025	6.69 ± 0.11	0.153 ± 0.002^b	26.00 ± 1.67^a
*Hypercholesterolemic mice*
Control ND	-	6.43 ± 0.77	0.133 ± 0.004	36.18 ± 2.17
Control HCBD	-	7.19 ± 0.13^b	0.150 ± 0.002^a	50.09 ± 5.81^a
SAqFSC-P/HCBD	1	7.17 ± 0.11	0.140 ± 0.005^c	47.26 ± 3.58
	3	7.06 ± 0.16	0.153 ± 0.003	46.32 ± 2.52
PAqFSC-P/HCBD	1	6.99 ± 0.16	0.147 ± 0.004	47.31 ± 3.38
	3	7.04 ± 0.13	0.156 ± 0.003	43.60 ± 3.90
Bicyclol/HCBD	0.025	7.25 ± 0.06	0.149 ± 0.003	29.30 ± 1.52^c

Experimental details were described in Figure1 and Table1. Mice were fed with ND or HCBD containing SAqFSC-P, PAqFSC-P, or bicyclol at the indicated concentration for 10 days. Hepatic index (liver weight/body weight × 100), protein (use Bradford assay) and function indicated by alanine aminotransferase (ALT) were then measured. Mouse model of hypercholesterolemia was generated by HCBD. Values given are the means ± S.E.M., with n = 10. ^aP < 0.05, ^bP < 0.01 vs. control ND; ^cP < 0.05 vs. control HCBD, using a one-way ANOVA follow by Dunnett’s multiple comparisons test or post-hoc analysis.

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