Skip to main content

Advertisement

Table 2 Effects of dietary supplementation with SAqFSC-P, PAqFSC-P, or bicyclol on hepatic index, protein and function in normal and hypercholesterolemic mice

From: Dietary pulp from Fructus Schisandra Chinensis supplementation reduces serum/hepatic lipid and hepatic glucose levels in mice fed a normal or high cholesterol/bile salt diet

Groups Drug concentration (%, w/w) Hepatic index (%) Hepatic protein (g/g liver tissue) Serum ALT activity (U/L)
Normal mice     
Control ND - 6.59 ± 0.10 0.138 ± 0.003 36.50 ± 3.61
SAqFSC-P/ND 1 6.76 ± 0.13 0.131 ± 0.003 27.60 ± 0.72a
  9 6.91 ± 0.13 0.140 ± 0.004 30.33 ± 2.41
PAqFSC-P/ND 1 6.73 ± 0.11 0.146 ± 0.002a 32.80 ± 1.63
  9 7.16 ± 0.17b 0.155 ± 0.003b 32.00 ± 1.81
Bicyclol/ND 0.025 6.69 ± 0.11 0.153 ± 0.002b 26.00 ± 1.67a
Hypercholesterolemic mice     
Control ND - 6.43 ± 0.77 0.133 ± 0.004 36.18 ± 2.17
Control HCBD - 7.19 ± 0.13b 0.150 ± 0.002a 50.09 ± 5.81a
SAqFSC-P/HCBD 1 7.17 ± 0.11 0.140 ± 0.005c 47.26 ± 3.58
  3 7.06 ± 0.16 0.153 ± 0.003 46.32 ± 2.52
PAqFSC-P/HCBD 1 6.99 ± 0.16 0.147 ± 0.004 47.31 ± 3.38
  3 7.04 ± 0.13 0.156 ± 0.003 43.60 ± 3.90
Bicyclol/HCBD 0.025 7.25 ± 0.06 0.149 ± 0.003 29.30 ± 1.52c
  1. Experimental details were described in Figure1 and Table1. Mice were fed with ND or HCBD containing SAqFSC-P, PAqFSC-P, or bicyclol at the indicated concentration for 10 days. Hepatic index (liver weight/body weight × 100), protein (use Bradford assay) and function indicated by alanine aminotransferase (ALT) were then measured. Mouse model of hypercholesterolemia was generated by HCBD. Values given are the means ± S.E.M., with n = 10. aP < 0.05, bP < 0.01 vs. control ND; cP < 0.05 vs. control HCBD, using a one-way ANOVA follow by Dunnett’s multiple comparisons test or post-hoc analysis.