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Table 2 The content of fatty acids (wt%) in plasma and erythrocytes of rats at a high-fat load

From: Effect of the prolonged high-fat diet on the fatty acid metabolism in rat blood and liver

Fatty acid Source High-fat load
30 days 90 days 180 days
   Control Experiment Control Experiment Control Experiment
14:0 Erythrocyte 0.52 ± 0.04 *0.83 ± 0.08 / 1.6↑ 0.48 ± 0.04 0.5 ± 0.06 0.50 ± 0.03 ***1.01 ± 0.12 / 2↑
Plasma PL 0.50 ± 0.04 ***1.22 ± 0.20 / 2.2↑ 0.62 ± 0.04 0.57 ± 0.05 0.60 ± 0.07 **0.37 ± 0.04 / 1.6↓
Plasma TAG 1.43 ± 0.10 *1.71 ± 0.10 / 1.2↑ 1.50 ± 0.10 1.53 ± 0.15 1.48 ± 0.10 *0.87 ± 0.11 / 1.7↓
Plasma ES 1.05 ± 0.06 1.23 ± 0.01 0.95 ± 0.09 0.84 ± 0.06 1.10 ± 0.05 ***0.42 ± 0.05 / 2.5↓
15:0 Erythrocyte 0.52 ± 0.04 0.58 ± 0.07 0.72 ± 0.06 **0.43 ± 0.02 / 1.7↓ 0.76 ± 0.07 *0.56 ± 0.04 / 1.4↓
Plasma PL 0.75 ± 0.06 ***1.33 ± 0.07 / 1.7↑ 0.72 ± 0.05 ***0.45 ± 0.02 / 1.6↓ 0.68 ± 0.05 ***0.40 ± 0.01 / 1.7↓
Plasma TAG 0.92 ± 0.08 ***1.55 ± 0.07 / 1.6↑ 0.90 ± 0.10 0.86 ± 0.05 0.94 ± 0.07 **0.52 ± 0.08 / 1.8↓
Plasma ES 0.80 ± 0.02 ***1.36 ± 0.09 / 1.7↑ 0.84 ± 0.04 ***0.41 ± 0.03 / 2↓ 0.93 ± 0.02 ***0.35 ± 0.01 / 2.6↓
16:0 Erythrocyte 23.72 ± 0.84 24.38 ± 0.57 24.12 ± 0.68 ***28.6 ± 0.5 / 1.2↑ 24.72 ± 0.74 **27.6 ± 1.4 / 1.1↑
Plasma PL 28.50 ± 0.33 27.68 ± 0.56 26.50 ± 0.43 25.64 ± 0.83 28.70 ± 0.30 27.02 ± 0.36
Plasma TAG 28.16 ± 2.24 26.42 ± 0.68 27.60 ± 2.00 24.23 ± 1.66 28.86 ± 1.80 **22.2 ± 0.52 / 1.3↓
Plasma ES 17.32 ± 3.49 15.67 ± 1.66 17.18 ± 1.00 ***11.47 ± 0.43 / 1.5↓ 17.00 ± 0.09 ***11.32 ± 0.12 / 1.5↓
16:1n-7 Erythrocyte 1.90 ± 0.25 1.83 ± 0.12 1.88 ± 0.22 ***0.83 ± 0.05 / 2.3↓ 2.04 ± 0.30 2.04 ± 0.21
  Plasma PL 1.2 ± 0.1 ***3.31 ± 0.40 / 2.7↑ 1.1 ± 0.2 0.91 ± 0.07 1.1 ± 0.6 1.17 ± 0.14
  Plasma TAG 6.57 ± 0.34 *8.67 ± 0.14 / 1.3↑ 7.56 ± 0.30 ***2.53 ± 0.27 / 3↓ 8.10 ± 0.46 *2.72 ± 0.39 / 3↓
  Plasma ES 5.35 ± 0.59 ***8.14 ± 0.77 / 1.6↑ 5.20 ± 0.40 *3.28 ± 57.14 / 1.6↓ 5.15 ± 0.90 4.75 ± 0.19
18:0 Erythrocyte 10.10 ± 0.50 **14.68 ± 0.48 / 1.4↑ 10.7 ± 0.45 ***17.3 ± 0.57 / 1.7↑ 9.9 ± 0.40 ***13.9 ± 1.77 / 1.4↑
Plasma PL 19.00 ± 0.37 *21.67 ± 0.94 / 1.1↑ 19.40 ± 0.67 ***23.23 ± 0.14 / 1.2↑ 18.70 ± 0.70 18.97 ± 0.72
Plasma TAG 5.00 ± 0.03 *3.00 ± 0.16 / 1.6↓ 4.80 ± 0.10 ***8.72 ± 0.91 / 1.8↑ 5.10 ± 0.30 4.92 ± 0.34
Plasma ES 3.75 ± 0.54 3.72 ± 0.46 3.45 ± 0.94 3.35 ± 0.22 3.70 ± 0.50 3.15 ± 0.56
18:1n-9 Erythrocyte 7.66 ± 0.57 **11.45 ± 1.22 / 1.5↑ 7.51 ± 0.70 **10.5 ± 0.31 / 1.4↑ 8.16 ± 0.67 **11.2 ± 1.38 / 1.4↑
Plasma PL 6.77 ± 0.41 7.67 ± 0.28 6.14 ± 0.50 6.91 ± 2.09 6.35 ± 0.60 *9.52 ± 0.34 / 1.5↑
Plasma TAG 25.27 ± 2.26 26.5 ± 2.36 27.70 ± 2.20 30.66 ± 1.87 26.10 ± 1.20 ***36.55 ± 1.14 / 1.4↑
Plasma ES 22.30 ± 3.7 ***11.5 ± 0.9 / 2↓ 21.64 ± 2.0 ***36.8 ± 2.7 / 1.7↑ 21.30 ± 1.70 ***46.5 ± 0.8 / 2.2↑
18:2n-6 Erythrocyte 14.02 ± 0.64 ***9.78 ± 0.23 / 1.4↓ 13.12 ± 0.64 12.6 ± 0.4 14.62 ± 0.84 **11.3 ± 0.97 / 1.3↓
Plasma PL 18.50 ± 0.6 18.85 ± 1.05 18.9 ± 0.60 18.12 ± 1.21 17.8 ± 0.50 18.30 ± 0.20
Plasma TAG 19.62 ± 2.86 ***15.3 ± 1.1 / 1.2↓ 20.20 ± 2.00 20.23 ± 1.40 18.82 ± 1.80 *17.12 ± 0.16 / 1.1↓
Plasma ES 19.25 ± 1.19 19.17 ± 1.35 20.25 ± 1.10 21.08 ± 0.96 18.40 ± 1.00 ***13.12 ± 0.2 / 1.4↓
20:3n-9 Erythrocyte 0.35 ± 0.12 tr 0.27 ± 0.10 0.17 ± 0.03 0.31 ± 0.10 ***0.95 ± 0.09 / 3↑
Plasma PL 0.55 ± 0.02 ***0.27 ± 0.02 / 2↓ 0.54 ± 0.10 ***0.25 ± 0.09 / 2↓ 0.62 ± 0.12 0.65 ± 0.02
Plasma TAG 0.72 ± 0.05 ***0.30 ± 0.01 / 2.4↓ 0.77 ± 0.08 0.73 ± 0.12 0.74 ± 0.06 ***1.45 ± 0.34/ 2↑
Plasma ES 0.96 ± 0.17 0.83 ± 0.31 0.94 ± 0.14 ***0.45 ± 0.05 / 2.1↓ 0.89 ± 0.20 0.75 ± 0.17
20:3n-6 Erythrocyte 0.60 ± 0.13 0.88 ± 0.09 0.62 ± 0.10 **1.23 ± 0.06 / 2↑ 0.70 ± 0.10 0.9 ± 0.08
Plasma PL 1.77 ± 0.39 1.38 ± 0.12 1.82 ± 0.30 2.05 ± 0.14 2.10 ± 0.70 *3.05 ± 0.29
Plasma TAG 0.77 ± 0.38 ***0.27 ± 0.20 / 2.8↓ 0.67 ± 0.30 0.51 ± 0.06 0.70 ± 0.30 0.72 ± 0.19
Plasma ES 0.42 ± 0.06 *0.66 ± 0.08 / 1.5↑ 0.52 ± 0.10 0.55 ± 0.06 0.48 ± 0.09 0.47 ± 0.02
20:4n-6 Erythrocyte 6.78 ± 1.70 ***21.27 ± 1.92 / 3.1↑ 6.80 ± 1.20 ***16.3 ± 0.5 / 2.4↑ 6.90 ± 1.72 ***15.9 ± 0.94 / 2.3↑
Plasma PL 12.2 ± 0.72 ***7.56 ± 0.62 / 1.7↓ 12.8 ± 0.80 13.66 ± 0.72 13.0 ± 0.80 **9.80 ± 0.60 / 1.3↓
Plasma TAG 2.45 ± 0.65 ***0.87 ± 0.16 / 2.7↓ 2.50 ± 0.60 2.38 ± 0.25 2.20 ± 0.50 2.11 ± 0.32
Plasma ES 28.73 ± 7.34 **18.84 ± 2.73 / 1.5↓ 30.54 ± 3.30 ***10.96 ± 0.86 / 2.8↓ 28.50 ± 2.40 ***10.55 ± 0.90 / 2.7↓
20:5n-3 Erythrocyte 0.90 ± 0.13 0.73 ± 0.09 0.86 ± 0.10 *0.58 ± 0.05 0.93 ± 0.12 **0.68 ± 0.05
Plasma PL 0.42 ± 0.13 ***1.55 ± 0.18 / 3.7↑ 0.48 ± 0.10 0.62 ± 0.11 0.50 ± 0.10 0.50 ± 0.10
Plasma TAG 0.70 ± 0.03 ***1.17 ± 0.11 / 1.6↑ 0.72 ± 0.08 *0.92 ± 0.13 / 1.3↑ 0.73 ± 0.07 **0.95 ± 0.05 / 1.3↑
Plasma ES 0.70 ± 0.20 tr 0.75 ± 0.10 ***1.24 ± 0.12 / 1.7↑ 0.80 ± 0.20 0.95 ± 0.11
22:4n-6 Erythrocyte 0.58 ± 0.07 **1.58 ± 0.09 / 3↑ 0.53 ± 0.07 **0.85 ± 0.05 / 1.6↑ 0.56 ± 0.06 0.66 ± 0.08
Plasma PL 0.15 ± 0.05 *0.33 ± 0.08 / 2↑ 0.14 ± 0.07 ***0.48 ± 0.06 / 3.2↑ 0.15 ± 0.05 0.15 ± 0.04
Plasma TAG 0.30 ± 0.01 0.27 ± 0.01 0.20 ± 0.05 tr 0.31 ± 0.06 ***0.61 ± 0.02 / 2↑
Plasma ES 0.24 ± 0.04 tr tr tr tr tr
22:5n-6 Erythrocyte 0.23 ± 0.15 *0.55 ± 0.05 / 2.5↑ 0.22 ± 0.10 ***0.17 ± 0.03 / 1.3↓ 0.21 ± 0.12 ***0.53 ± 0.13 / 2.5↑
Plasma PL 0.20 ± 0.01 tr 0.23 ± 0.05 ***0.55 ± 0.01 / 2.4↑ 0.15 ± 0.05 tr
Plasma TAG tr tr tr 0.20 ± 0.01 tr tr
Plasma ES 0.10 ± 0.07 tr tr tr tr 0.20 ± 0.01
22:5n-3 Erythrocyte 1.32 ± 0.16 1.62 ± 0.27 1.22 ± 0.14 1.38 ± 0.09 1.12 ± 0.17 1.15 ± 0.27
Plasma PL 0.62 ± 0.13 ***0.92 ± 0.10 / 1.5↑ 0.60 ± 0.15 0.61 ± 0.08 0.67 ± 0.20 0.65 ± 0.06
Plasma TAG 0.50 ± 0.02 ***1.05 ± 0.13 / 2↑ 0.64 ± 0.08 0.74 ± 0.11 0.54 ± 0.06 ***0.25 ± 0.07 / 2↓
Plasma ES 0.15 ± 0.05 tr tr 0.36 ± 0.09 tr 0.17 ± 0.02
22:6n-3 Erythrocyte 5.53 ± 0.12 *3.93 ± 0.11 / 1.4↓ 4.53 ± 0.16 **2.22 ± 0.08 / 2↓ 5.38 ± 0.17 ***2.85 ± 0.53 / 1.9↓
Plasma PL 3.22 ± 0.47 4.45 ± 0.50 3.00 ± 0.70 3.27 ± 0.24 3.80 ± 0.80 4.27 ± 0.35
Plasma TAG 1.45 ± 0.13 *2.93 ± 0.09 / 2↑ 1.85 ± 0.40 2.46 ± 0.33 1.10 ± 0.10 ***3.25 ± 0.32 / 3↑
Plasma ES 1.65 ± 0.38 1.95 ± 0.11 1.35 ± 0.30 1.14 ± 0.12 1.74 ± 0.28 ***0.87 ± 0.14 / 2↓
  1. Mean ± m, n = 10.
  2. Note: TAG, triacylglycerols; PL, phospholipids; ES, esters of sterols; tr, traces less than 0.1%. Asterisks indicate significant differences of fatty acid contents between rats from experimental group and corresponding control group: *for P < 0.05; **for P < 0.01, ***for P < 0.001. The numbers in boldface after the slash indicate the change of the value for the experimental group relative to that of the control group in the number of times. The arrow indicates that the value decreased. The arrow indicates that the value increased.