From: Risk stratification of patients with familial hypercholesterolemia in a multi-ethnic cohort
Score | ||
---|---|---|
Family history | ||
First degree relative with known premature coronary and vascular disease (Men <55 yrs, Females <60 yrs), | 1 | |
OR | ||
First degree relative with LDL cholesterol above the 95th percentile for age and sex | ||
First degree relative with tendionous xanthomata and/or arcus cornealis, | 2 | |
OR | ||
Children <18 yrs with LDL cholesterol above the 95th percentile for age and sex | ||
Clinical history | ||
Patient with premature coronary artery disease (ages as above) | 2 | |
Patient with premature cerebral or peripheral vascular disease (ages as above) | 1 | |
Physical examination | ||
Tendinous xanthomata | 6 | |
Arcus cornealis prior to age 45 yrs | 4 | |
LDL cholesterol (mmol/L) | ||
LDL-C ≥ 8.5 | 8 | |
LDL-C 6.5-8.4 | 5 | |
LDL-C 5.0-6.4 | 3 | |
LDL-C 4.0-4.9 | 1 | |
DNA analysis- functional mutation in the LDLR, APOB, or PCSK9 gene | 8 | |
Stratification | Total score | |
Definite FH | ≥8 | |
Probable FH | 6-7 | |
Possible FH | 3-5 | |
Unlikely FH | <3 |