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Table 1 Dutch lipid clinic network criteria

From: Risk stratification of patients with familial hypercholesterolemia in a multi-ethnic cohort

 

Score

Family history

First degree relative with known premature coronary and vascular disease (Men <55 yrs, Females <60 yrs),

1

OR

 

First degree relative with LDL cholesterol above the 95th percentile for age and sex

 

First degree relative with tendionous xanthomata and/or arcus cornealis,

2

OR

 

Children <18 yrs with LDL cholesterol above the 95th percentile for age and sex

 

Clinical history

Patient with premature coronary artery disease (ages as above)

2

Patient with premature cerebral or peripheral vascular disease (ages as above)

1

Physical examination

Tendinous xanthomata

6

Arcus cornealis prior to age 45 yrs

4

LDL cholesterol (mmol/L)

 
 

LDL-C ≥ 8.5

8

 

LDL-C 6.5-8.4

5

 

LDL-C 5.0-6.4

3

 

LDL-C 4.0-4.9

1

DNA analysis- functional mutation in the LDLR, APOB, or PCSK9 gene

8

Stratification

Total score

Definite FH

≥8

Probable FH

6-7

Possible FH

3-5

Unlikely FH

<3

  1. Modified from Civeira [3] with permission from Elsevier.