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Table 1 Changes of lipid profile and other variables (n = 10, each group)

From: Synergistic effects of colchicine combined with atorvastatin in rats with hyperlipidemia

Variables

Sham

Control

Atorvastatin

Colchicine

Combined

Before the beginning of the study

     

TG (mmol/L)

0.93 ± 0.11

0.98 ± 0.14

0.93 ± 0.12

0.95 ± 0.10

0.96 ± 0.15

TC (mmol/L)

3.04 ± 0.35

3.11 ± 0.32

3.08 ± 0.27

3.06 ± 0.30

3.09 ± 0.33

LDL-C (mmol/L)

1.99 ± 0.24

1.98 ± 0.21

2.01 ± 0.29

1.97 ± 0.19

2.01 ± 0.24

HDL-C (mmol/L)

1.03 ± 0.08

1.03 ± 0.07

1.05 ± 0.07

1.04 ± 0.06

1.04 ± 0.05

CRP (mg/L)

1.24 ± 0.16

1.27 ± 0.13

1.32 ± 0.16

1.25 ± 0.19

1.24 ± 0.13

ALT (U/L)

24.5 ± 3.8

25.8 ± 3.0

25.2 ± 1.9

24.2 ± 1.7

26.0 ± 2.8

AST (U/L)

28.3 ± 2.3

27.6 ± 2.7

28.2 ± 2.4

29.1 ± 3.2

28.8 ± 2.5

6 weeks of model production

     

TG (mmol/L)

0.98 ± 0.13*

2.15 ± 0.33

2.22 ± 0.37

2.19 ± 0.28

2.20 ± 0.27

TC (mmol/L)

3.08 ± 0.32*

5.87 ± 0.66

5.93 ± 0.61

5.91 ± 0.57

5.89 ± 0.60

LDL-C (mmol/L)

1.97 ± 0.21*

3.76 ± 0.55

3.79 ± 0.53

3.80 ± 0.51

3.78 ± 0.52

HDL-C (mmol/L)

1.05 ± 0.06

1.07 ± 0.04

1.08 ± 0.02

1.07 ± 0.04

1.06 ± 0.03

CRP (mg/L)

1.30 ± 0.13*

7.25 ± 1.08

7.20 ± 1.03

7.18 ± 1.08

7.22 ± 1.05

ALT (U/L)

27.8 ± 3.2

29.2 ± 3.6

28.5 ± 2.4

26.2 ± 1.4

26.8 ± 2.0

AST (U/L)

28.2 ± 3.5

28.2 ± 2.5

28.7 ± 2.0

28.3 ± 2.7

27.4 ± 1.9

2 weeks of therapy

     

TG (mmol/L)

0.98 ± 0.13*

2.13 ± 0.25

1.98 ± 0.16

2.11 ± 0.22

1.97 ± 0.16

TC (mmol/L)

3.05 ± 0.24*

5.65 ± 0.48#

4.85 ± 0.41

5.85 ± 0.55&

4.64 ± 0.43

LDL-C (mmol/L)

1.93 ± 0.20*

3.70 ± 0.51#

2.92 ± 0.22

3.71 ± 0.38&

2.88 ± 0.25

HDL-C (mmol/L)

1.05 ± 0.03

1.06 ± 0.05

1.11 ± 0.03

1.08 ± 0.03

1.12 ± 0.03

CRP (mg/L)

1.32 ± 0.12*

7.19 ± 1.02#

5.35 ± 0.93

4.03 ± 0.65&

2.87 ± 0.45

ALT (U/L)

26.3 ± 4.1

27.8 ± 1.4

28.2 ± 2.6

27.4 ± 1.8

26.3 ± 2.5

AST (U/L)

27.4 ± 3.0

27.6 ± 2.1

28.2 ± 2.4

28.0 ± 2.1

27.3 ± 1.4

  1. Denote: *P < 0.05 versus other groups; #P < 0.05 versus Atorvastatin and Combined groups; &P < 0.05 versus Atorvastatin and Combined groups; &P < 0.05 versus Control, Atorvastatin and Colchicine groups.