From: Synergistic effects of colchicine combined with atorvastatin in rats with hyperlipidemia
Variables | Sham | Control | Atorvastatin | Colchicine | Combined |
---|---|---|---|---|---|
Before the beginning of the study | |||||
TG (mmol/L) | 0.93 ± 0.11 | 0.98 ± 0.14 | 0.93 ± 0.12 | 0.95 ± 0.10 | 0.96 ± 0.15 |
TC (mmol/L) | 3.04 ± 0.35 | 3.11 ± 0.32 | 3.08 ± 0.27 | 3.06 ± 0.30 | 3.09 ± 0.33 |
LDL-C (mmol/L) | 1.99 ± 0.24 | 1.98 ± 0.21 | 2.01 ± 0.29 | 1.97 ± 0.19 | 2.01 ± 0.24 |
HDL-C (mmol/L) | 1.03 ± 0.08 | 1.03 ± 0.07 | 1.05 ± 0.07 | 1.04 ± 0.06 | 1.04 ± 0.05 |
CRP (mg/L) | 1.24 ± 0.16 | 1.27 ± 0.13 | 1.32 ± 0.16 | 1.25 ± 0.19 | 1.24 ± 0.13 |
ALT (U/L) | 24.5 ± 3.8 | 25.8 ± 3.0 | 25.2 ± 1.9 | 24.2 ± 1.7 | 26.0 ± 2.8 |
AST (U/L) | 28.3 ± 2.3 | 27.6 ± 2.7 | 28.2 ± 2.4 | 29.1 ± 3.2 | 28.8 ± 2.5 |
6 weeks of model production | |||||
TG (mmol/L) | 0.98 ± 0.13* | 2.15 ± 0.33 | 2.22 ± 0.37 | 2.19 ± 0.28 | 2.20 ± 0.27 |
TC (mmol/L) | 3.08 ± 0.32* | 5.87 ± 0.66 | 5.93 ± 0.61 | 5.91 ± 0.57 | 5.89 ± 0.60 |
LDL-C (mmol/L) | 1.97 ± 0.21* | 3.76 ± 0.55 | 3.79 ± 0.53 | 3.80 ± 0.51 | 3.78 ± 0.52 |
HDL-C (mmol/L) | 1.05 ± 0.06 | 1.07 ± 0.04 | 1.08 ± 0.02 | 1.07 ± 0.04 | 1.06 ± 0.03 |
CRP (mg/L) | 1.30 ± 0.13* | 7.25 ± 1.08 | 7.20 ± 1.03 | 7.18 ± 1.08 | 7.22 ± 1.05 |
ALT (U/L) | 27.8 ± 3.2 | 29.2 ± 3.6 | 28.5 ± 2.4 | 26.2 ± 1.4 | 26.8 ± 2.0 |
AST (U/L) | 28.2 ± 3.5 | 28.2 ± 2.5 | 28.7 ± 2.0 | 28.3 ± 2.7 | 27.4 ± 1.9 |
2 weeks of therapy | |||||
TG (mmol/L) | 0.98 ± 0.13* | 2.13 ± 0.25 | 1.98 ± 0.16 | 2.11 ± 0.22 | 1.97 ± 0.16 |
TC (mmol/L) | 3.05 ± 0.24* | 5.65 ± 0.48# | 4.85 ± 0.41 | 5.85 ± 0.55& | 4.64 ± 0.43 |
LDL-C (mmol/L) | 1.93 ± 0.20* | 3.70 ± 0.51# | 2.92 ± 0.22 | 3.71 ± 0.38& | 2.88 ± 0.25 |
HDL-C (mmol/L) | 1.05 ± 0.03 | 1.06 ± 0.05 | 1.11 ± 0.03 | 1.08 ± 0.03 | 1.12 ± 0.03 |
CRP (mg/L) | 1.32 ± 0.12* | 7.19 ± 1.02# | 5.35 ± 0.93 | 4.03 ± 0.65& | 2.87 ± 0.45※ |
ALT (U/L) | 26.3 ± 4.1 | 27.8 ± 1.4 | 28.2 ± 2.6 | 27.4 ± 1.8 | 26.3 ± 2.5 |
AST (U/L) | 27.4 ± 3.0 | 27.6 ± 2.1 | 28.2 ± 2.4 | 28.0 ± 2.1 | 27.3 ± 1.4 |