Table 2 Insulin secretion and insulin sensitivity in patients with DM-NAFLD and those with T2DM only

Fasting C-peptide (nmol/l)

1.56 ± 0.9

2.2 ± 0.97

0.045

2-h OGTT

3.37 ± 1.66

4.95 ± 2.16

0.008

ΔC-peptide 30 min (pmol/l)

0.506 ± 0.9

0.97 ± 0.74

0.045

ΔC-p/PG 30 min ratio

0.137 ± 0.1

0.247 ± 0.182

0.011

AUC C-p (pmol/l)

323.39 ± 161.13

466.71 ± 208.51

0.007

AUC C-p/PG ratio

0.18 ± 0.09

0.27 ± 0.13

0.008

AUC C-p 30–120 min (pmol/l)

255.16 ± 128.93

385.9 ± 178.06

0.003

AUC C-p/PG 30–120 min ratio

0.186 ± 0.097

0.281 ± 0.139

0.006

AUC C-p 120–180 min

105.55 ± 48.21

149.21 ± 67.54

0.009

AUC C-p/PG 120–180 min

0.235 ± 0.128

0.619 ± 0.179

0.025

Muscle insulin sensitivity index

0.209 ± 1.71

0.34 ± 0.56

NS

HOMA2-B%

97.62 ± 50.66

107.33 ± 44.86

NS

HOMA2-S%

31.39 ± 20.31

23.65 ± 11.97

NS

HOMA-IR

4.44 ± 2.5

5.4 ± 2.9

NS