LPA rs10455872 polymorphism is associated with coronary lesions in Brazilian patients submitted to coronary angiography

Table 1 General characteristics, biochemical, hemodynamic, and angiographic data according to LPA rs10455872 genotypes in the patients submitted to coronary angiography

	Genotypes		p value
(n=1394,100%)	AA(n=1223)	AG+GG(n=171)
Age ( years )	59.9 ± 10.1	59.5 ± 10.8	0.62
Gender , female (%)	40.6	37.4	0.42
Race / color (%)
White	65.0	74.9
Intermediate	29.8	23.4	0.02
Black	5.2	1.8
Hypertension (%)	70.0	68.4	0.68
Diabetes (%)	31.2	27.5	0.33
Hyperlipidemia (%)	57.2	71.3	0.002
Statin use (%)	28.0	30.5	0.61
Smokers (%)	35.6	38.0	0.44
Body mass index ( Kg / m ² )	27.7 ± 4.8	27.6 ± 4.9	0.99
Total cholesterol ( mg / dL )	228 ± 49	237 ± 46	0.05
LDL - C ( mg / dL )	147 ± 44	155 ± 39	0.11
HDL - C ( mg / dL )	42 ± 12	42 ± 10	0.82
Triglycerides ( mg / dL )	183 ± 130	179 ± 108	0.75
Systolic blood pressure ( mmHg )	149 ± 34	152 ± 39	0.61
Diastolic blood pressure ( mmHg )	82 ± 15	84 ± 15	0.29
Ejection fraction (%)	60.6 ± 14.4	56.8 ± 17.7	0.07
Coronary lesions (%)	79.6	88.9	0.004
Extension score	2.1 ± 1.6	2.6 ± 1.7	<0.001
Severity score	1.5 ± 1.2	1.9 ± 1.3	<0.001
Gensini score	19.7 ± 28.2	25.7 ± 32.0	0.05

HDL-C: high density lipoprotein; LDL-C: low density lipoprotein.
Biochemical data, blood pressures, and angiographic scores were adjusted for age, gender, and race/color.
Coronary lesions frequency was compared between normal coronary arteries versus one-vessel, two-vessel, and three-vessel disease.

ISSN: 1476-511X