The results of qPCR showed that high fat diet (HD) significantly decreased the expression of LXRα, ABCG5, ABCG8, SR-BI, CYP7A1 and LCAT,and CMS alone significantly elevated the expression of LXRα, ABCG5, ABCG8, and SR-BI, while CMS + HD significantly decreased the expression of ABCG5, ABCG8, CYP7A1 and LCAT. The data of mRNA expression were presented as mean ± SEM. *P < 0.05 and **P < 0.01: compared to Control; ◊◊P < 0.01: compared to HD group; ##P < 0.01: compared to CMS group, all with one-way ANOVA. The results of Western blot showed similar trends. The blots shown on gels respectively represented the group of Control, CMS, CMS + HD, HD.