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Table 3 Genotyping and allele distributions in control subjects and patients with CAD in the Han population

From: Association of Egr 3 genetic polymorphisms and coronary artery disease in the Uygur and Han of China

 

Total

Men

Women

Variants

CAD patients

Control subjects

P value

CAD patients

Control subjects

P value

CAD patients

Control subjects

P value

rs1996147

         

Genotyping

         

AA

45(11.0%)

49(14.0%)

 

35(11.7%)

28(15.6%)

 

10(9.2%)

21(12.2%)

 

AG

199(48.7%)

156(44.4%)

 

150(50.0%)

77(43.1%)

 

49(45.0%)

79(45.9%)

 

GG

165(40.3%)

146(41.6%)

0.346

115(38.3%)

74(41.3%)

0.252

50(45.8%)

72(41.9%)

0.664

Dominant model

         

GG

165(40.3%)

146(41.6%)

 

115(38.3%)

74(41.3%)

 

50(45.8%)

72(41.9%)

 

AA + AG

244(59.7%)

205(58.4%)

0.726

185(61.7%)

105(58.7%)

0.515

59(54.2%)

100(58.1%)

0.509

Recessive model

         

AA

45(11.0%)

49(14.0%)

 

35(11.7%)

28(15.6%)

 

10(9.2%)

21(12.2%)

 

GG + AG

364(89.0%)

302(86.0%)

0.217

265(88.3%)

151(84.4%)

0.213

99(90.8%)

151(87.8%)

0.429

Additive model

         

AG

199(48.7%)

156(44.4%)

 

150(50.0%)

77(43.1%)

 

49(45.0%)

79(45.9%)

 

AA + GG

210(51.3%)

195(55.6%)

0.246

150(50.0%)

102(56.9%)

0.139

60(55.0%)

93(54.1%)

0.873

Allele

         

A

289(35.3%)

254(36.2%)

 

220(36.7%)

133(37.2%)

 

69(31.7%)

121(35.2%)

 

G

529(64.7%)

448(63.8%)

0.730

380(63.3%)

225(62.8%)

0.881

149(68.3%)

223(64.8%)

0.390

rs1008949

         

Genotyping

         

CC

112(27.4%)

99(28.2%)

 

85(28.3%)

55(30.7%)

 

30(27.5%)

44(25.6%)

 

CT

204(49.9%)

173(49.3%)

 

149(49.7%)

84(46.9%)

 

55(50.5%)

89(51.7%)

 

TT

93(22.7%)

79(22.5%)

0.969

69(23.0%)

40(22.4%)

0.817

24(22.0%)

39(22.7%)

1.000

Dominant model

         

CC

112(27.4%)

99(28.2%)

 

85(28.3%)

55(30.7%)

 

30(27.5%)

44(25.6%)

 

TT + CT

297(72.6%)

252(71.8%)

0.801

218(72.7%)

124(69.3%)

0.532

79(72.5%)

128(74.4%)

0.719

Recessive model

         

TT

93(22.7%)

79(22.5%)

 

69(23.0%)

40(22.4%)

 

24(22.0%)

39(22.7%)

 

CC + CT

316(77.3%)

272(77.5%)

0.939

234(77.0%)

139(77.6%)

0.914

85(78.0%)

133(77.3%)

0.995

Additive model

         

CT

204(49.9%)

173(49.3%)

 

149(46.7%)

84(46.9%)

 

55(50.5%)

89(51.7%)

 

CC + TT

205(50.1%)

178(50.7%)

0.871

154(51.3%)

95(53.1%)

0.633

54(49.5%)

83(48.3%)

0.982

Allele

         

C

428(52.3%)

371(52.8%)

 

319(53.2%)

194(54.2%)

 

115(52.8%)

177(51.5%)

 

T

390(47.7%)

331(47.2%)

0.838

287(47.8%)

164(45.8%)

0.641

103(47.2%)

167(48.5%)

0.993

  1. CAD, coronary artery disease; SNP, single-nucleotide polymorphism.