Table 4 Genotyping and allele distributions in control subjects and patients with CAD in the Uygur population
From: Association of Egr 3 genetic polymorphisms and coronary artery disease in the Uygur and Han of China
Total | Men | Women | |||||||
|---|---|---|---|---|---|---|---|---|---|
Variants | CAD patients | Control subjects | P value | CAD patients | Control subjects | P value | CAD patients | Control subjects | P value |
rs1996147 | |||||||||
Genotyping | |||||||||
AA | 109(36.5%) | 75(24.7%) | 77(38.9%) | 49(25.0%) | 32(31.7%) | 26(24.3%) | |||
AG | 142(47.5%) | 156(51.5%) | 90(45.5%) | 98(50.0%) | 52(51.5%) | 58(54.2%) | |||
GG | 48(16.0%) | 72(23.8%) | 0.003* | 31(15.6%) | 49(25.0%) | 0.005* | 17(16.8%) | 23(21.5%) | 0.433 |
Dominant model | |||||||||
GG | 48(16.0%) | 72(23.8%) | 31(15.6%) | 49(25.0%) | 17(16.8%) | 23(21.5%) | |||
AA + AG | 251(84.0%) | 231(76.2%) | 0.018* | 167(84.4%) | 147(75.0%) | 0.021* | 84(83.2%) | 84(78.5%) | 0.394 |
Recessive model | |||||||||
AA | 109(36.5%) | 75(24.7%) | 77(38.9%) | 49(25.0%) | 32(31.7%) | 26(24.3%) | |||
GG + AG | 190(63.5%) | 228(75.3%) | 0.002* | 121(61.1%) | 147(75.0%) | 0.003* | 69(68.3%) | 81(75.7%) | 0.235 |
Additive model | |||||||||
AG | 142(47.5%) | 156(51.5%) | 90(45.5%) | 98(50.0%) | 52(51.5%) | 58(54.2%) | |||
AA + GG | 157(52.5%) | 147(48.5%) | 0.327 | 108(54.5%) | 98(50.0%) | 0.366 | 49(48.5%) | 49(45.8%) | 0.694 |
Allele | |||||||||
A | 360(60.2%) | 306(50.5%) | 244(61.6%) | 196(50.0%) | 116(57.4%) | 110(51.4%) | |||
G | 238(39.8%) | 300(49.5%) | 0.001* | 152(38.4%) | 196(50.0%) | 0.001* | 86(42.6%) | 104(48.6%) | 0.218 |
rs1008949 | |||||||||
Genotyping | |||||||||
CC | 118(39.5%) | 104(34.3%) | 77(38.9%) | 66(33.7%) | 41(40.6%) | 38(35.5%) | |||
CT | 136(45.5%) | 152(50.2%) | 95(48.0%) | 98(50.0%) | 41(40.6%) | 54(50.5%) | |||
TT | 45(15.0%) | 47(15.5%) | 0.409 | 26(13.1%) | 32(16.3%) | 0.472 | 19(18.8%) | 15(14.0%) | 0.334 |
Dominant model | |||||||||
CC | 118(39.5%) | 104(34.3%) | 77(38.9%) | 66(33.7%) | 41(40.6%) | 38(35.5%) | |||
TT + CT | 181(60.5%) | 199(65.7%) | 0.191 | 121(61.1%) | 130(66.3%) | 0.282 | 60(59.4%) | 69(64.5%) | 0.451 |
Recessive model | |||||||||
TT | 45(15.0%) | 47(15.5%) | 26(13.1%) | 32(16.3%) | 19(18.8%) | 15(14.0%) | |||
CC + CT | 254(85.0%) | 256(84.5%) | 0.875 | 172(86.9%) | 164(83.7%) | 0.371 | 82(81.2%) | 92(86.0%) | 0.350 |
Additive model | |||||||||
CT | 136(45.5%) | 152(50.2%) | 95(48.0%) | 98(50.0%) | 41(40.6%) | 54(50.5%) | |||
CC + TT | 163(54.5%) | 151(49.8%) | 0.267 | 103(52.0%) | 98(50.0%) | 0.688 | 60(59.4%) | 53(49.5%) | 0.153 |
Allele | |||||||||
C | 372(62.2%) | 360(59.4%) | 249(62.9%) | 230(58.7%) | 123(60.9%) | 130(60.7%) | |||
T | 226(37.8%) | 246(40.6%) | 0.319 | 147(37.1%) | 162(41.3%) | 0.227 | 79(39.1%) | 84(39.3%) | 0.976 |