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Table 4 Genotyping and allele distributions in control subjects and patients with CAD in the Uygur population

From: Association of Egr 3 genetic polymorphisms and coronary artery disease in the Uygur and Han of China

  Total Men Women
Variants CAD patients Control subjects P value CAD patients Control subjects P value CAD patients Control subjects P value
rs1996147          
Genotyping          
AA 109(36.5%) 75(24.7%)   77(38.9%) 49(25.0%)   32(31.7%) 26(24.3%)  
AG 142(47.5%) 156(51.5%)   90(45.5%) 98(50.0%)   52(51.5%) 58(54.2%)  
GG 48(16.0%) 72(23.8%) 0.003* 31(15.6%) 49(25.0%) 0.005* 17(16.8%) 23(21.5%) 0.433
Dominant model          
GG 48(16.0%) 72(23.8%)   31(15.6%) 49(25.0%)   17(16.8%) 23(21.5%)  
AA + AG 251(84.0%) 231(76.2%) 0.018* 167(84.4%) 147(75.0%) 0.021* 84(83.2%) 84(78.5%) 0.394
Recessive model          
AA 109(36.5%) 75(24.7%)   77(38.9%) 49(25.0%)   32(31.7%) 26(24.3%)  
GG + AG 190(63.5%) 228(75.3%) 0.002* 121(61.1%) 147(75.0%) 0.003* 69(68.3%) 81(75.7%) 0.235
Additive model          
AG 142(47.5%) 156(51.5%)   90(45.5%) 98(50.0%)   52(51.5%) 58(54.2%)  
AA + GG 157(52.5%) 147(48.5%) 0.327 108(54.5%) 98(50.0%) 0.366 49(48.5%) 49(45.8%) 0.694
Allele          
A 360(60.2%) 306(50.5%)   244(61.6%) 196(50.0%)   116(57.4%) 110(51.4%)  
G 238(39.8%) 300(49.5%) 0.001* 152(38.4%) 196(50.0%) 0.001* 86(42.6%) 104(48.6%) 0.218
rs1008949          
Genotyping          
CC 118(39.5%) 104(34.3%)   77(38.9%) 66(33.7%)   41(40.6%) 38(35.5%)  
CT 136(45.5%) 152(50.2%)   95(48.0%) 98(50.0%)   41(40.6%) 54(50.5%)  
TT 45(15.0%) 47(15.5%) 0.409 26(13.1%) 32(16.3%) 0.472 19(18.8%) 15(14.0%) 0.334
Dominant model          
CC 118(39.5%) 104(34.3%)   77(38.9%) 66(33.7%)   41(40.6%) 38(35.5%)  
TT + CT 181(60.5%) 199(65.7%) 0.191 121(61.1%) 130(66.3%) 0.282 60(59.4%) 69(64.5%) 0.451
Recessive model          
TT 45(15.0%) 47(15.5%)   26(13.1%) 32(16.3%)   19(18.8%) 15(14.0%)  
CC + CT 254(85.0%) 256(84.5%) 0.875 172(86.9%) 164(83.7%) 0.371 82(81.2%) 92(86.0%) 0.350
Additive model          
CT 136(45.5%) 152(50.2%)   95(48.0%) 98(50.0%)   41(40.6%) 54(50.5%)  
CC + TT 163(54.5%) 151(49.8%) 0.267 103(52.0%) 98(50.0%) 0.688 60(59.4%) 53(49.5%) 0.153
Allele          
C 372(62.2%) 360(59.4%)   249(62.9%) 230(58.7%)   123(60.9%) 130(60.7%)  
T 226(37.8%) 246(40.6%) 0.319 147(37.1%) 162(41.3%) 0.227 79(39.1%) 84(39.3%) 0.976
  1. CAD, coronary artery disease; SNP, single-nucleotide polymorphism; *P < 0.05.