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Table 1 Baseline characteristics according to the tertiles of serum hemoglobin A1C levels

From: Glycosylated hemoglobin A1c as a marker predicting the severity of coronary artery disease and early outcome in patients with stable angina

Variables Tertiles of serum hemoglobin A1C levels (%) P-value
Total (n = 1433) Low (<5.7; n = 483) Intermediate (5.7 ~ 6.3; n = 512) High (>6.3; n = 438)
Demographic      
Age, years 58.3 ± 10.2 55.5 ± 10.8 59.6 ± 9.6 59.8 ± 9.5 <0.001
Male gender 1008(69.9) 365(75.6) 350(68.3) 293(66.9) 0.008
Risk factors Body mass index (kg/m2) 25.5 ± 3.2 25.0 ± 3.0 25.4 ± 3.3 26.0 ± 3.2 <0.001
Current Smoking 770(53.4) 271(56.1) 272(53.1) 227(51.8) 0.404
Hypertension 909(63.4) 280(58.0) 317(61.9) 312(71.2) <0.001
Diabetes mellitus 374(26.1) 89(18.4) 93(18.2) 192(43.8) <0.001
Hyperlipidemia 1064(74.2) 306(63.4) 393(76.8) 365(83.3) <0.001
Peripheral vascular disease 26(1.8) 6(1.2) 11(2.1) 9(2.1) 0.509
Prior Stroke 68(4.7) 16(3.3) 27(5.3) 25(5.7) 0.182
Family history of CAD 158(11.0) 44(9.1) 55(10.7) 59(13.5) 0.104
Laboratory date      
LVEF (%) 62.2 ± 8.1 62.5 ± 8.2 62.1 ± 8.2 62.2 ± 7.9 0.672
NT-pro-BNP (fmol/mL) 710.4 ± 515.7 663.9 ± 422.7 720.8 ± 492.3 749.5 ± 622.1 0.036
FBG (mmol/L) 5.5 ± 1.5 6.8 ± 2.1 5.0 ± 0.6 4.7 ± 0.6 <0.001
Haemoglobin (g/L) 139.9 ± 15.1 141.5 ± 14.9 139.7 ± 14.7 138.3 ± 15.9 0.006
Leucocyte count (109/L) 6.4 ± 1.6 6.2 ± 1.6 6.4 ± 1.6 6.6 ± 1.7 0.002
Platelet count (109/L) 205.1 ± 60.7 201.8 ± 68.6 208.4 ± 58.6 204.9 ± 53.7 0.221
Fibrinogen (g/L) 3.2 ± 0.8 2.9 ± 0.6 3.2 ± 0.7 3.3 ± 0.9 <0.001
D-dimer (mg/dL) 0.4 ± 0.7 0.3 ± 0.4 0.4 ± 0.6 0.3 ± 1.0 0.023
hs-CRP (mg/L) 2.9 ± 3.6 2.1 ± 2.9 3.0 ± 3.5 3.6 ± 4.1 <0.001
Endothelin-1 (fmol/mL) 0.6 ± 0.3 0.6 ± 0.3 0.6 ± 0.3 0.6 ± 0.3 0.492
Albumin (g/L) 41.8 ± 3.5 41.6 ± 3.3 41.9 ± 3.8 41.8 ± 3.4 0.491
Cr (umol/L) 75.6 ± 16.2 75.4 ± 13.8 75.4 ± 17.1 76.2 ± 17.5 0.686
UA (mmol/L) 347.4 ± 4.2 354.0 ± 83.3 348.8 ± 80.5 338.5 ± 88.8 0.017
Lipid profile      
Triglycerides (mmol/L) 4.2 ± 1.1 4.1 ± 0.9 4.2 ± 1.1 4.1 ± 1.1 0.008
Total cholesterol (mmol/L) 4.2 ± 1.1 4.0 ± 0.9 4.2 ± 1.1 4.2 ± 1.1 0.077
LDL-C (mmol/L) 2.5 ± 0.9 2.5 ± 0.9 2.5 ± 0.8 2.5 ± 0.9 0.497
HDL-C (mmol/L) 1.1 ± 0.3 1.1 ± 0.3 1.1 ± 0.2 1.1 ± 0.3 0.051
Lipoprotein (a) (mg/L) 236.9 ± 244.6 220.6 ± 224.7 265.6 ± 263.4 221.4 ± 240.4 0.004
ApoA (g/L) 1.5 ± 0.3 1.5 ± 0.3 1.5 ± 0.2 1.5 ± 0.3 0.920
ApoB (g/L) 1.1 ± 0.3 1.0 ± 0.3 1.1 ± 0.3 1.1 ± 0.3 0.157
Medical treatment      
Aspirin 1358(94.8) 444(91.9) 490(95.7) 424(96.8) 0.002
Clopidogrel 1297(90.5) 416(86.1) 473(92.4) 408(93.2) <0.001
Beta-blocker 1129(78.8) 351(72.7) 415(81.1) 363(82.9) <0.001
ACE-I 424(29.6) 132(27.3) 162(31.6) 130(29.7) 0.389
Statin 1332(93.0) 429(88.8) 486(94.9) 417(95.2) <0.001
DES implantation 250(17.4) 60(12.4) 109(21.3) 81(18.5) 0.001
  1. CAD = Coronary artery disease; LV-FE = Left ventricular ejection fraction; hs-CRP = high sensitivity C-reactive protein; LDL-C = Low density lipoprotein cholesterol; HDL-C = High density lipoprotein cholesterol; ACE-I = Angiotensin converting enzyme inhibitors; DES = Drug eluting stent.