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Table 1 Fatty acid composition of the phosphatidylcholine fraction within mammary glands adjacent to tumours

From: Mammary tumour development is dose-dependently inhibited by n-3 polyunsaturated fatty acids in the MMTV-neu(ndl)-YD5 transgenic mouse model

Mammary gland PC fatty acids

Diet

0%

3%

9%

LA (18:2n-6)

30.8 ± 2.1a

20.9 ± 2.3b

11.9 ± 1.6c

AA (20:4n-6)

8.3 ± 0.5a

3.8 ± 0.2b

7.9 ± 2.1ab

DPA (22:5n-6)

0.8 ± 0.1a

traceb

traceb

ALA (18:3n-3)

tracea

tracea

tracea

EPA (20:5n-3)

tracea

0.7 ± 0.1b

4.0 ± 0.8c

DPA (22:5n-3)

tracea

0.3 ± 0.4ab

1.9 ± 0.9b

DHA (22:6n-3)

tracea

tracea

tracea

Total n-6

41.4 ± 1.7a

25.2 ± 2.1b

20.3 ± 1.2c

Total n-3

0.03 ± 0.03a

1.1 ± 0.5b

6.0 ± 1.5c

n-6/n-3 ratio

1292.3a

23.8 ± 8.5b

3.4 ± 1.0c

Total SFA

43.6 ± 1.1a

45.9 ± 0.4ab

52.6 ± 0.9b

Total MUFA

14.1 ± 1.7a

23.4 ± 2.0a

21.0 ± 1.9b

Total PUFA

41.7 ± 1.3a

26.4 ± 2.6b

26.4 ± 1.4c

P/S Ratio

1.0 ± 0.1a

0.6 ± 0.04b

0.5 ± 0.05c

  1. n = 4 for the 3% n-3 PUFA diet, n = 5 for both the 0% n-3 and 9% n-3 PUFA dietary interventions. Values in the same row not sharing the same superscript are significantly different from one another as determined by a one-way ANOVA (p < 0.05).