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Figure 4 | Lipids in Health and Disease

Figure 4

From: Atorvastatin helps preserve pancreatic β cell function in obese C57BL/6 J mice and the effect is related to increased pancreas proliferation and amelioration of endoplasmic-reticulum stress

Figure 4

Atorvastatin attenuates cholesterol-induced apoptosis of NIT-1 cells. (A) Effects of atorvastatin alone on NIT-1 cell viability. (n = 3–5) (B) Reserved β-cell relative viability after addition of different concentrations (10-9 to 10-5 M) of atorvastatin under treatment with 0.125 mM cholesterol for 12 h. Values are means ± S.E.M. (n = 3). (C) NIT-1 cell apoptosis with or without treatment of cholesterol and in addition of 10-8 M atorvastatin incubation for 18 h. Results were detected by flow cytometry and quantification was made based on propidium iodide (PI) positive cells. (n = 3) (D) Protein expression of anti-apoptotic Bcl-2 in the pancreas. All the data were expressed as mean ± S.E.M. *P < 0.05, **P < 0.01, ***P < 0.001 vs. the CHO group; ##P < 0.01, ###P < 0.001 vs. control.

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Lipids in Health and Disease

ISSN: 1476-511X