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Table 7 Fecal bile acids and neutral sterols in minipigs treated with G. lucidum and lovastatin (nmol/g dry feces)

From: Cholesterol-lowering properties of Ganoderma lucidum in vitro, ex vivo, and in hamsters and minipigs

  Bile acids Neutral Sterols
Group NCT C CDC COP-ol COP-3-one CHOL erol CHOL anol
All pigs (D1) 1.98 0.86 0.66a 2.41a 0.10a 1.73a* 0.96
All pigs (D14) 1.98 1.33 0.16 3.75 0.17 2.96 0.91
Gl (D14) 1.98 1.61 0.14 3.61 0.18 3.37 0.87b*
Gl (D29) 1.98 0.81 0.16 4.44 0.15 3.15 1.22
Lovastatin (D14) 1.98 0.99 0.19 3.92 0.15 2.44 0.96
Lovastatin (D29) 1.98 1.23 0.18 3.28 0.16 2.34 1.14
  1. Feces were collected on D1, 14 and 29. A quantitative fecal collection was not possible, hence results are expressed per gram of feces. Abbreviations: refer to Table 4, except, NCT, 23- Nor β cholanate 5α,7α,12α triol. A paired, 2-tailed students t-test, equal variances, evaluated effects of the high cholesterol and fat diet, between D1-14 (10 minipigs); and the effects of Gl or lovastatin between D15-29 (5 minipigs/group), indicated as follows: aD1 vs 14, for all minipigs combined (P < 0.001).bD14 vs 29 (P < 0.05). *0.05 < P < 0.1, to indicate statistical trends.