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Table 1 Synopsis of the updated ATP III LDL-C Goals and Cut-points for TLC and Drug Therapy in Different Risk Categories and Proposed Modifications Based on Recent Clinical Trial Evidence

From: The pivotal role of cholesterol absorption inhibitors in the management of dyslipidemia

Risk Category Goal TLC Drug Therapy
High risk: CHD or CHD risk equivalents (10-year risk >20%) < 100 mg/dL (optional goal: <70 mg/dL) ≥ 100 mg/dL ≥ 100 (<100 mg/dL: consider drug options)
Moderately high risk: 2+ risk factors (10-year risk 10% to 20%) < 130 mg/dL ≥ 130 mg/dL ≥ 130 mg/dL(100–129 mg/dL; consider drug options)
Moderate risk: 2+ risk factors (10-year risk <10%) < 130 mg/dL ≥ 130 mg/dL ≥ 160 mg/dL
Lower risk: 0–1 risk factor < 160 mg/dL ≥ 160 mg/dL ≥ 190 mg/dL (160–189 mg/dL: LDL-lowering drug optional)