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Table 2 Serum cholesterol concentration (mmol/L) at baseline and after two 3-week periods of coffee abstention (week 0 – 3 and week 7 – 10) for APOE ε2-positive (n = 13) and APOE ε2-negative (n = 108) individuals

From: The apolipoprotein E polymorphism and the cholesterol-raising effect of coffee

  APOE ε2-positive APOE ε2-negative p
  n = 13 n = 107/103 a  
First trial period    
week 0 4.68 (0.80) 5.28 (0.93) 0.01b
week 3 4.49 (0.71) 5.05 (0.90)  
diff week 0–3 -0.18 (0.24) -0.23 (0.55) 0.30 c
p (diff 0–3) 0.02 d <0.0001d  
Second trial period    
week 7 4.52 (0.71) 5.34 (0.93)  
week 10 4.34 (0.64) 4.95 (0.89)  
week 7–10 -0.18 (0.41) -0.39 (0.55) 0.08 c
p (diff 7–10) 0.13 <0.0001d  
  1. a 107 participants in the first trial period and 103 participants in the second trial period
  2. b Significant difference between APOE ε2-positive and APOE ε2-negative at baseline, Wilcoxon rank sum test
  3. c No significant difference between APOE ε2-positive and APOE ε2-negative in differences between week 0–3 or week 7–10, Wilcoxon rank sum test
  4. d Significant difference between week 0–3 for the APOE ε2-positive group and between week 0–3 and week 7–10 for the APOE ε2-negative group, Signed rank test