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Table 3 Statistical significance of serum fasting glucose level and lipid profile in diabetic-hypercholesterolemic rats treated with bezafibrate, quinazolinone and halogenated derivatives.

From: The antihyperlipidemic activities of 4(3H) quinazolinone and two halogenated derivatives in rats

Parameters C C+B C+Q C+BrQ C+IQ
Glucose(mg/dl)      
Mean ± SD 210.34 ± 16.56a 173.82 ± 26.86b 68.40 ± 5.22c 71.32 ± 8.42c 68.60 ± 5.66c
Range (189.24–230.00) (140.00–218.00) (61.65–79.47) (60.55–85.00) (60.76–75.36)
Change% - -17.36 -67.48 -66.09 -67.39
Total lipids(g/L)      
Mean ± SD 6.25 ± 2.29a 4.76 ± 0.85b 3.23 ± 1.08c 3.14 ± 0.63c 3.28 ± 0.77c
Range (2.32–9.51) (3.76–5.96) (2.02–4.64) (2.02–4.15) (2.20–4.34)
Change% - -23.84 -48.32 -49.76 -47.52
T.G(mg/dl)      
Mean ± SD 110.42 ± 18.75a 91.91 ± 15.64a 109.51 ± 31.98a 99.00 ± 15.06a 100.64 ± 10.33a
Range (88.14–133.33) (70.00–111.11) (66.67–165.00) (73.33–121.14) (86.67–117.11)
Change% - -16.76 -0.82 -10.34 -9.72
T.Cholesterol(mg/dl)      
Mean ± SD 176.28 ± 42.14a 152.76 ± 36.36a 99.31 ± 22.80b 88.38 ± 26.64b 89.69 ± 10.02b
Range (127.34–224.38) (106.25–199.22) (74.22–126.56) (65.63–134.38) (73.44–104.22)
Change% - -13.34 -43.66 -49.86 -49.12
F.Cholesterol(mg/dl)      
Mean ± SD 39.19 ± 11.02ab 44.37 ± 9.44a 30.31 ± 6.98b 30.03 ± 6.73b 31.06 ± 5.43b
Range (25.62–51.89) (28.62–53.98) (20.16–40.98) (23.09–41.30) (26.02–41.63)
Change% - 13.22 -22.66 -23.37 -20.75
E.Cholesterol(mg/dl)      
Mean ± SD 135.37 ± 31.41a 108.39 ± 31.2b 69.00 ± 18.80c 60.46 ± 16.43c 58.56 ± 6.96c
Range (101.72–170.75) (77.63–145.24) (49.18–96.97) (48.40–88.08) (47.42–65.67)
Change% - -19.93 -62.33 -55.34 -56.74
HDL-C(mg/dl)      
Mean ± SD 24.76 ± 3.62a 25.88 ± 2.74a 24.87 ± 4.71a 26.71 ± 2.58a 22.50 ± 1.77a
Range (18.00–27.94) (21.13–29.60) (19.83–31.52) (22.40–30.33) (19.80–24.32)
Change% - 4.52 0.44 7.88 -9.13
LDL-C(mg/dl)      
Mean ± SD 115.29 ± 34.06a 84.56 ± 43.44a 32.58 ± 18.85b 39.56 ± 26.65b 45.26 ± 10.16b
Range (79.73–168.69) (44.05–137.56) (19.51–64.94) (16.24–82.42) (34.31–63.03)
Change% - -26.65 -71.74 -65.69 -60.74
VLDL-C(mg/dl)      
Mean ± SD 22.08 ± 3.75a 18.38 ± 3.13a 22.52 ± 6.28a 19.80 ± 3.01a 20.13 ± 2.07a
Range (17.63–26.67) (14.00–22.22) (13.33–33.00) (14.67–24.23) (17.33–23.42)
Change% - -1.67 1.99 -10.33 -8.83
A.I.      
Mean ± SD 6.27 ± 2.06a 4.49 ± 1.53b 3.12 ± 1.20b 1.91 ± 1.27b 3.01 ± 0.57b
Range (3.56–9.80) (2.59–6.91) (1.65–4.82) (0.99–4.33) (2.21–3.79)
Change% - -28.39 -50.24 -69.54 -51.99
  1. For each parameter similar characters denote insignificance between groups.
  2. The mean difference is significant at p < 0.05.