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Table 4 Statistical significance of hepatic lipid profile and malondialdehyde concentration in hypercholesterolemic rats treated with bezafibrate, quinazolinone and halogenated derivatives, compared to control group

From: The antihyperlipidemic activities of 4(3H) quinazolinone and two halogenated derivatives in rats

Parameters HCD HCD+B HCD+Q HCD+BrQ HCD+IQ
Total lipids      
Mean ± SD 75.30 ± 7.86a 60.16 ± 4.18b 52.11 ± 13.07b 56.47 ± 9.50b 56.32 ± 12.94b
Range (68.24–88.24) (54.90–66.27) (36.86–74.90) (41.57–68.24) (41.57–76.08)
Change% - -20.11 -30.80 -25.01 -25.21
Triacylglycerol      
Mean ± SD 10.55 ± 2.66a 6.01 ± 1.39b 9.83 ± 2.17a 7.85 ± 2.75b 8.05 ± 1.35b
Range (7.09–14.91) (4.09–7.83) (7.30–13.91) (4.39–11.74) (6.65–10.50)
Change% - -43.03 -6.82 -25.59 -23.70
Total cholesterol      
Mean ± SD 25.18 ± 2.77ab 25.64 ± 1.48a 22.71 ± 2.13b 22.80 ± 2.01b 22.83 ± 2.13b
Range (20.58–28.46) (23.98–28.32) (19.11–25.85) (20.00–25.39) (19.12–25.61)
Change% - 1.83 -9.81 -9.45 -9.33
Free cholesterol      
Mean ± SD 5.80 ± 1.70a 5.23 ± 1.32a 12.78 ± 2.46b 9.64 ± 1.30c 9.47 ± 1.50c
Range (3.37–8.13) (3.85–6.83) (9.52–17.33) (7.68–11.45) (7.22–11.51)
Change% - -9.83 120.34 66.21 63.28
Ester cholesterol      
Mean ± SD 19.38 ± 1.67a 20.42 ± 1.00a 9.56 ± 1.56b 13.16 ± 1.30c 13.36 ± 1.20c
Range (16.99–21.76) (19.35–22.47) (7.57–11.43) (11.11–14.51) (11.67–15.56)
Change% - 5.37 -50.67 -32.09 -31.06
MDA(nmol/g)      
Mean ± SD 131.31 ± 15.10a 229.73 ± 4.76b 214.18 ± 23.85b 196.75 ± 26.44b 211.16 ± 14.54b
Range (113.33–155.42) (223.53–238.43) (172.42–246.01) (161.57–229.28) (188.37–230.33)
Change% - 74.95 63.11 49.84 60.81
  1. All parameters are expressed in mg/g tissue unless otherwise stated.
  2. For each parameter similar characters denote insignificance between groups.
  3. The mean difference is significant at p < 0.05.