Figure 1

Intestinal polyamine oxidase activity in LPA transgenic and non-transgenic mice. The mice were fed two different diets, one high in fat and cholesterol (HFHC diet), the other a standard diet low in fat. Some of the animals from each group (see Table 1) were treated with 0.5% AG (aminiguanidine) in the drinking water. After 100 days of treatment the activity of the enzyme was assayed. The number of mice in each group is given with numbers within each column. Experimental details are given in Materials and Methods. The histograms represent means with SD indicated. Population means that were significantly different from the non-transgenic mice are denoted with asterisk, * (p < 0.05).