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Table 1 Selenium levels in liver (μg/g) and serum (μg/L), GSH-Px levels in liver (μmoles of NADPH oxidized/min/mg protein) after 1 and 2 months of control and high cholesterol diet (HCD) feeding.

From: Hypercholesterolemia and apolipoprotein B expression: Regulation by selenium status

Treatment period

Se deficient group

Se adequate group

Se excess group

 

Control Ia

HCD Ib

Control IIa

HCD IIb

Control IIIa

HCD IIIb

Se in liver

      

1 month

1.83 ± 0.26DDD

1.20 ± 0.14***###

3.85 ± 0.29

3.11 ± 0.39**

4.57 ± 0.43LL

2.51 ± 0.29***B

2 months

1.23 ± 0.22DDDAA

0.73 ± 0.05***AAA###

3.97 ± 0.36

2.54 ± 0.27***A

6.51 ± 0.65AAALLL

4.38 ± 0.44***AAABBB

Se in serum

      

1 month

1.54 ± 0.15DDD

0.76 ± 0.04***###

2.51 ± 0.24

2.11 ± 0.27*

3.84 ± 0.34LLL

2.62 ± 0.27***BB

2 month

0.98 ± 0.07DDDAAA

0.51 ± 0.02***AAA###

2.82 ± 0.29

1.62 ± 0.17***AA

4.73 ± 0.39AALLL

3.58 ± 0.31***AAABBB

GSH-Px

      

1 month

281.45 ± 34.89DDD

354.19 ± 32.79**###

387.42 ± 25.86

467.19 ± 27.66***

568.82 ± 52.94LLL

686.19 ± 50.58**BBB

2 month

160.33 ± 22.78DDDAAA

463.73 ± 39.91***AAA###

393.16 ± 49.67

593.28 ± 35.38***AAA

672.91 ± 58.16AALLL

825.16 ± 63.85**AABBB

  1. Data is represented as mean ± SD from 6 observations.
  2. *p<0.05, **p<0.01, ***p<0.001 represent comparison between control and HCD groups; Ap<0.05, AAp<0.01, AAAp<0.001 comparison between 1 and 2 months; DDDp<0.001 comparison between group Ia and IIa; ###p<0.001 comparison between group Ib and IIb; LLp<0.01, LLLp<0.001 comparison between group IIa and IIIa; Bp<0.05, BBp<0.01, BBBp<0.001 comparison between group IIb and IIIb.