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Figure 7 | Lipids in Health and Disease

Figure 7

From: Prolonged treatment of genetically obese mice with conjugated linoleic acid improves glucose tolerance and lowers plasma insulin concentration: possible involvement of PPAR activation

Figure 7

Effect of the c9, t11 and t10, c12-enriched CLA on (a) PPARγ- and (b) PPARα mediated gene expression. Cos-7 cells were transiently transfected with the plasmids pPPRE3TK-luc, pRLTK, pRSV/hRXRα and pcDNA3/hPPARγ 1 (a) or pcDNA3/hPPARα (b). Transfected cells were treated for 46 (a) or 24 (b) hours. Cell extracts were assayed for firefly and renilla luciferase activity. Reporter gene activity was determined by normalising firefly luciferase activity against renilla luciferase activity. The CLA isomers were prepared in 0.1% DMSO so that each of the stated isomers was at the given concentration. * P < 0.05 and ** P < 0.01; n = 6.

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Lipids in Health and Disease

ISSN: 1476-511X