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Table 1 Effect of LDL and oxLDL on superoxide dismutase isoenzymes in macrophages.

From: Human macrophages limit oxidation products in low density lipoprotein

 

CuZnSOD

U/mg cell protein

MnSOD

U/mg cell protein

EC-SOD

secreted ng/mg cell protein

Control 2 h

81.1 ± 7.5

8.1 ± 0.7

0.61 ± 0.28

LDL 2 h

70.9 ± 8.1

8.2 ± 0.7

0.59 ± 0.23

oxLDL 2 h

71.8 ± 9.0

7.4 ± 0.4

0.45 ± 0.15

Control 24 h

79.3 ± 12.1

18.6 ± 1.8 (P = 0.0016)

0.86 ± 0.35

LDL 24 h

80.8 ± 9.9

15.4 ± 0.7 (P = 0.0004)

0.85 ± 0.31

oxLDL 24 h

91.2 ± 20.6

17.1 ± 1.9 (P = 0.0025)

0.80 ± 0.30

  1. Values are means ± SE (n = 4). CuZn-SOD and Mn-SOD enzymatic activities were measured in cell lysates, and EC-SOD protein was determined in culture media. P values indicate the comparison between the effect of LDL/oxLDL on superoxide dismutase at 2 h and 24 h.