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Table 1 Effect of LDL and oxLDL on superoxide dismutase isoenzymes in macrophages.

From: Human macrophages limit oxidation products in low density lipoprotein

  CuZnSOD U/mg cell protein MnSOD U/mg cell protein EC-SOD secreted ng/mg cell protein
Control 2 h 81.1 ± 7.5 8.1 ± 0.7 0.61 ± 0.28
LDL 2 h 70.9 ± 8.1 8.2 ± 0.7 0.59 ± 0.23
oxLDL 2 h 71.8 ± 9.0 7.4 ± 0.4 0.45 ± 0.15
Control 24 h 79.3 ± 12.1 18.6 ± 1.8 (P = 0.0016) 0.86 ± 0.35
LDL 24 h 80.8 ± 9.9 15.4 ± 0.7 (P = 0.0004) 0.85 ± 0.31
oxLDL 24 h 91.2 ± 20.6 17.1 ± 1.9 (P = 0.0025) 0.80 ± 0.30
  1. Values are means ± SE (n = 4). CuZn-SOD and Mn-SOD enzymatic activities were measured in cell lysates, and EC-SOD protein was determined in culture media. P values indicate the comparison between the effect of LDL/oxLDL on superoxide dismutase at 2 h and 24 h.