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Table 2 List of genes identified by literature mining that modulate homocysteine levels

From: Mining literature for a comprehensive pathway analysis: A case study for retrieval of homocysteine related genes for genetic and epigenetic studies

S.No Symbol Gene Name Function
1. Mthfr Methylenetetrahydrofolate Reductase Conversion of 5, 10-methylene-tetrahydrofolate to 5-methyl-tetrahydrofolate.
2. Cbs Cystathionine beta-synthase Condensation of homo-cysteine and serine to form cystathionine
3. Mtr Methyltetrahydrofolatehomocysteine methyltransferase Remethylation of homocysteine to methionine
4. Mtrr Methionine synthase reductase Reductive regeneration of cob(I)alamin cofactor required for the maintenance of MTR in a functional state
5. Rfc-1 Reduced-folate carrier 5-methyl-tetrahydrofolate internalization in cell
6 Gcp II/Folh1 Glutamate Carboxypeptidase II Polyglutamate converted to monoglutamate folate by action of the enzyme folylpoly gammaglutamate carboxy-peptidase (FGCPI), an enzyme expressed by GCPII.
7 eNos Endothelial Nitric oxide synthase Conversion of L-Arginine to L-Citrulline and nitric oxide synthase (NO)
8. Tc II Transcobalamine II Transport of vitamin B12
9. Shmt1 Serine Hydroxymethyltransferase 1 Reversible conversion of serine and tetrahydrofolate to glycine and 5, 10-methylene tetrahydrofolate.
10. Tyms Thymidylate Synthase 5, 10-methylene THF and deoxyuridylate to form dihydro-folate and thymidylate.
11 Cth Cystathionine Gamma-Lyase Hydrolysis of cystathionine to cysteine and α-Ketoglutarate
12 Mthfd Methylene-tetra hydrofolate dehydrogenase Conversion of 5, 10-methylene-tetrahydrofolate to5, 10methenyl-tetrahydrofolate.
13 Mthfs Methenyltetrahydrofolate synthetase Conversion of 5-formyltetrahydrofolate to 5, 10-methenyltetrahydrofolate.
14 Apo E Apolipoproteine E Mediates the binding, internalization, and catabolism of lipoprotein particles.
15 Vegf Vascular endothelial growth factor Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth.
16 Pon1 Paraoxonase 1 Hydrolyzes the toxic organo-phosphorus. It also mediate an enzymatic protection of LDL against oxidative modification.
17 Bhmt Betaine-homocysteine methyltransferase In Liver & kidney it catalyses the conversion of betaine to dimethyl glycine (DMG).
18 Mat1A Methionine Adenosyltransferase 1A Methionine to SAM by transfer of the adenosyl moiety of ATP to the sulfur atom of methionine
19 Ahcy S-adenosylhomocysteine hydrolase Hydrolysis of AdoHcy to adenosine and homocysteine
20 Cbl Cystathionine beta lyase Conversion of cystathionine to homocysteine.
22 Factor V Coagulation factor V Cofactor for the factor Xa-catalyzed activation of prothrombin to the clotting enzyme thrombin.
23 Pai-1 Prothrombin activator inhibitor-1 Inhibition of fibrinolysis by inhibiting the plasminogen-activator and t-PA.