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Table 1 Influence of Caloric Restriction and Re-feeding on Plasma Metabolites in B6 Micea

From: Caloric restriction in C57BL/6J mice mimics therapeutic fasting in humans

Metabolites

UR

R

Difference(%)

R-RF

Fd(2,9)

Glucoseb

15.5 ± 0.86

9.1 ± 1.83**

41

12.5 ± 1.61*

18.3

β-hydroxybutyrateb

0.3 ± 0.12

1.4 ± 0.13**

367

0.3 ± 0.05

141.4

Neutral lipids c

     

Triglycerides

2.4 ± 0.63

1.0 ± 0.16*

-58

2.5 ± 1.00

6.1

Cholesterol

0.5 ± 0.23

0.2 ± 0.06*

-60

0.4 ± 0.14

3.7

Phosphatidylcholine

2.8 ± 0.53

1.7 ± 0.25**

-39

2.8 ± 0.30

10.3

Acidic Lipids c

     

Fatty acids

0.3 ± 0.08

0.8 ± 0.05**

167

0.3 ± 0.05

69.7

Phosphatidylinositol

0.2 ± 0.03

0.2 ± 0.01

0

0.2 ± 0.03

1.2

  1. a Values represent the mean ± 95% CI. Four independent samples were analyzed per group.
  2. b Values are expressed as mM.
  3. c Determined from densitometric scanning of HPTLC as shown in Figures 3 and 4. Values are expressed as mg lipid/ml plasma.
  4. d /F/ ratio and degree of freedom (df) obtained from one way analysis of variance.
  5. Astericks indicate that the value is significantly different from that of the control at the * p < 0.05 and ** p < 0.01 as determined by ANOVA followed by Fisher's PLSD