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Table 2 Influence of Fasting/Very Low Calorie Diet on Plasma Metabolites in Humansa

From: Caloric restriction in C57BL/6J mice mimics therapeutic fasting in humans

Metabolites Length (days) Unrestricted Fasted Difference (%) References  
Glucose 21 7.06 4.39 -38 Owen et al. 1998 [19]
  21–35 5.11 3.89 -24 Streja et al. 1977 [58]
β-hydroxybutyrate 2 0.03 1.67 5.E+03 Pan et al. 2000 [59]
  3 0.03 3.15 1.E+04   
  21 0.19 4.60 2.E+03 Owen et al. 1998 [19]
  21–35 0.11 4.56 4.E+03 Streja et al. 1977 [58]
Neutral lipids       
Triglycerides 7 3.46 2.50 -28 Balazsi et al. 1983 [29]
  14 3.46 1.77 -49   
  28 1.13 0.95 -16 Shoji et al. 1992 [30]
Cholesterol 7 4.90 6.73 37 Savendahl and Underwood 1999 [20]
  7 5.48 5.16 -6 Balazsi et al. 1983 [29]
  14 5.48 4.36 -20   
  14 5.14 4.01 -22 Schouten et al. 1981 [60]
  15 5.39 4.43 -18 Cominacini et al. 1991 [61]
  28 5.22 4.21 -19 Shoji et al. 1992 [30]
LDL Cholesterol 7 2.91 2.96 2 Balazsi et al. 1983 [29]
  14 2.91 2.43 -16   
Phosphatidylcholine 7 2.21 2.39 8 Savendahl et al. 1997 [62]
Acidic Lipids       
Fatty acids 21 0.84 1.19 42 Owen et al. 1998 [19]
  21–35 0.51 0.85 67 Streja et al. 1977 [58]
  1. a Values are expressed as mM.