Caloric restriction in C57BL/6J mice mimics therapeutic fasting in humans

Table 2 Influence of Fasting/Very Low Calorie Diet on Plasma Metabolites in Humans^a

Metabolites	Length (days)	Unrestricted	Fasted	Difference (%)	References
Glucose	21	7.06	4.39	-38	Owen et al. 1998	[19]
	21–35	5.11	3.89	-24	Streja et al. 1977	[58]
β-hydroxybutyrate	2	0.03	1.67	5.E+03	Pan et al. 2000	[59]
	3	0.03	3.15	1.E+04
	21	0.19	4.60	2.E+03	Owen et al. 1998	[19]
	21–35	0.11	4.56	4.E+03	Streja et al. 1977	[58]
Neutral lipids
Triglycerides	7	3.46	2.50	-28	Balazsi et al. 1983	[29]
	14	3.46	1.77	-49
	28	1.13	0.95	-16	Shoji et al. 1992	[30]
Cholesterol	7	4.90	6.73	37	Savendahl and Underwood 1999	[20]
	7	5.48	5.16	-6	Balazsi et al. 1983	[29]
	14	5.48	4.36	-20
	14	5.14	4.01	-22	Schouten et al. 1981	[60]
	15	5.39	4.43	-18	Cominacini et al. 1991	[61]
	28	5.22	4.21	-19	Shoji et al. 1992	[30]
LDL Cholesterol	7	2.91	2.96	2	Balazsi et al. 1983	[29]
	14	2.91	2.43	-16
Phosphatidylcholine	7	2.21	2.39	8	Savendahl et al. 1997	[62]
Acidic Lipids
Fatty acids	21	0.84	1.19	42	Owen et al. 1998	[19]
	21–35	0.51	0.85	67	Streja et al. 1977	[58]

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