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Table 1 Biopsy fatty acid-profiles from IBD-patients before and after seal oil treatment compared with controls

From: Short-term duodenal seal oil administration normalised n-6 to n-3 fatty acid ratio in rectal mucosa and ameliorated bodily pain in patients with inflammatory bowel disease

Fatty acid

Controls

IBD before

IBD after

P-value before

P-value after

Σ Saturated

36.9 ± 2.1

32 ± 1

31 ± 3

0.01

n.s.

14:0

2.9 ± 0.6

1.4 ± 0.3

1.2 ± 0.3

0.02

0.01

16:0

20.2 ± 0.4

17.9 ± 0.9

17 ± 1

0.008

0.02

17:0

0.90 ± 0.01

0.61 ± 0.08

0.7 ± 0.1

0.02

n.s.

18:0

11.1 ± 0.7

11 ± 1

12 ± 1

n.s.

n.s.

Σ Monoenes

31 ± 4

31 ± 2

24 ± 2

n.s.

0.003

16:1 n-7

1.9 ± 0.2

2.0 ± 0.5

1.5 ± 0.3

n.s.

n.s.

16:1 n-9

0.50 ± 0.01

0.40 ± 0.04

0.37 ± 0.05

n.s.

n.s.

18:1 n-7

2.3 ± 0.1

2.4 ± 0.2

2.0 ± 0.2

n.s.

n.s.

18:1 n-9

19 ± 1

25 ± 1

19 ± 1

0.004

n.s.

20:1 n-9

2.9 ± 0.6

0.13 ± 0.07

0.4 ± 0.3

0.0008

0.003

Σ n-6

17 ± 2

24 ± 2

19 ± 1

0.04

n.s.

18:2 n-6

11 ± 2

16 ± 1

12.1 ± 0.6

0.02

n.s.

20:3 n-6

tr.

1.5 ± 0.2

1.0 ± 0.1

< 0.0001

0.0004

20:4 n-6

5.7 ± 0.9

6 ± 1

6 ± 1

n.s.

n.s.

Σ n-3

9 ± 1

4.1 ± 0.5

9 ± 1

0.0004

n.s.

18:3 n-3

0.5 ± 0.1

0.4 ± 0.1

0.24 ± 0.08

n.s.

n.s.

20:5 n-3

2.6 ± 0.3

0.81 ± 0.05

3.4 ± 0.4

0.0003

n.s.

22:5 n-3

0.7 ± 0.1

0.6 ± 0.2

0.9 ± 0.2

n.s.

n.s.

22:6 n-3

4.6 ± 0.4

2.2 ± 0.3

4.3 ± 0.6

0.0006

n.s.

n-6/n-3

2.2 ± 0.4

6.6 ± 1.1

2.2 ± 0.2

0.001

n.s.

  1. Data from the pilot study [11], IBD-group (n = 10) and control group (n = 10). Data presented as percentage of fatty acids, mean ± SEM. Identified fatty acids ranged from 94–98 %. tr. = trace. n.s. = not significant (p > 0.05). P-value before = controls versus IBD-patients before seal oil treatment. P-value after = controls versus IBD-patients after seal oil treatment.