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Table 1 Comparison of the mean of biochemical factors before and after immunization in immunized rabbits fed normal and high cholesterol diet

From: Effect of immunization against ox-LDL with two different antigens on formation and development of atherosclerosis

High cholesterol diet

Normal diet

 

Cu-LDL

MDA-LDL

Control

Cu-LDL

MDA-LDL

Control

 

After immunization

Before immunization

After immunization

Before immunization

After immunization

Before immunization

After immunization

Before immunization

After immunization

Before immunization

After immunization

Before immunization

Biochemical factor (mg/dl)

503 ± 136.8

18.7 ± 11

403.6 ± 218*

16.8 ± 5.3

558.7 ± 42.2

13.8 ± 8.7

26 ± 15.0

15.3 ± 12.7

21 ± 9.5

19.1 ± 5.7

17.4 ± 11.8

22.2 ± 15.3

LDL-C

128 ± 19.3

39.6 ± 14

114 ± 26.5

35.4 ± 4.9

103 ± 6.2

33.6 ± 1.5

36.7 ± 2.3

29.2 ± 4.9

36.5 ± 3.5

36.5 ± 2.6

30.0 ± 15.3

35.0 ± 8.4

HDL-C

1.2 ± 2.3**

0.8 ± 0.2

2.4 ± 0.3

0.8 ± .24

2.1 ± 0.69

0.9 ± 0.44

1.04 ± 0.5

0.7 ± 0.3

1.1 ± 0.4

0.9 ± 0.25

1.04 ± 0.36

1.04 ± 0.63

CRP

198.8 ± 49.2*

116 ± 20.8

136 ± 41*

105 ± 39.8

254.8 ± 139.4

116 ± 31.4

110 ± 29.6

125.7 ± 19.5

150 ± 10.8

136 ± 16.7

77.0 ± 16.2

63.3 ± 26.6

TG

62.3 ± 3.7*

81.6 ± 9.6

62.3 ± 4.8*

85.4 ± 8.3

82.6 ± 15.7

80.2 ± 39.8

83.7 ± 7.9

58.7 ± 9.9

82 ± 17

58.5 ± 9.9

80.8 ± 11.3

70.0 ± 12.8

FBS

671 ± 144.6*

63.7 ± 15.2

545.8 ± 276.7*

58.8 ± 7.4

711.2 ± 63.4

68.2 ± 15.3

73 ± 18.0

64.7 ± 20.7

93 ± 16.9

55.7 ± 5.3

63.0 ± 27.1

71.0 ± 24.0

CHOL

  1. LDL-C: Low Density Lipoprotein, HDL-C: High Density Lipoprotein, CRP: C-Reactive Protein, TG: Triglyceride, FBS: Fasting Blood Sugar, CHOL: Cholesterol Measurements were expressed as Mean ± SD
  2. * Statistically significant difference with non- immunized high-cholesterol diet (P < 0.05)
  3. ** Statistically significant difference with non-immunized high-cholesterol diet and also with high cholesterol diet immunized with MDA-LDL (P < 0.05)