Table 1 A summary of the gene ontology data with respect to molecular function is given here. Changes in the expression of genes concerned with biological processes and cellular components are given in the text.
From: Gene expression profile in obesity and type 2 diabetes mellitus
S. No | Comparison | Up regulated genes | Down regulated genes |
|---|---|---|---|
1 | DPH vs H | NADH dehydrogenase (ubiquinone) Glutamate dehydrogenase [NAD(P)+] CDP-diacylglycerol-glycerol-3-phosphate-3-hosphitidltransferase | Protein kinase B binding Acyl-CoA oxidase Phosphatidylinositol transporter Acyltransferase |
2 | DNPH1 vs H | Hydroxyacylglutathione hydrolase NADH dehydrogenase (ubiquinone) GABA-B receptor Glutamate dehydrogenase [NAD(P)+] CDP-diacylglycerol-glycerol-3-phosphate-3-phosphatidyl transferase | MHC class II receptor Structural constituent of ribosome Hsp 70 protein binding L-tyrosine transporter Cyclin binding Arachidonate 5-lipoxygenase |
3 | DNPH2 vs H | Asparaginase activity Creatine: sodium symporter Phosphomannomutase activity Glutamate dehydrogenase [NAD(P)+] basic amino acid transporter Adenylosuccinate synthase | Structural constituent of ribosome MHC class II receptor MHC class I receptor L-tyrosine transporter N-acylmannosamine kinase |
4 | O vs H | Deformylase NADH dehydrogenase (ubiquinone) Glutamate dehydrogenase [NAD(P)+] Phosphomannomutase Transposase Carboxylic ester hydrolase Glutamate decarboxylase Mannosyltransferase Transforming growth factor beta binding | Glycolipid transporter activity Glycolipid binding 3-hydroxisobutyrate Dehydrogenase 25-hydroxycholecalciferol-24-hydroxylase |
5 | DPH vs O | Glycolipid transporter Calmodulin inhibitor Glycolipid binding Interleukin-22 receptor Oxygen transporter Antigen binding Lactate dehydrogenase Glyoxylate reductase (NADP) activity 25-hydroxycholecalciferol-24-hydroxylase activity Glycerate dehydrogenase Ubiquinol-cytochrome-c reductase | Amylo-alpha-1, 6 Glucosidase 4-alpha-glucanotransferase Interleukin-8 receptor activity |
6 | DPH and O | NADH dehydrogenase (ubiquinone) Glutamate dehydrogenase [NAD(P)+] Transposase Guanylate cyclase inhibitor | Hypoxanthine phosphoribosyltransferase Structural constituent of Ribosome NADP binding, and histone deacetylase |
7 | O vs HO | Transforming growth factor beta binding Sodium: amino acid symporter Adenosylhomocysteinase Transferase Transferring acyl groups Caspase activator NAD(P)H oxidase Steroid 21-monooxygenase Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) Glutamate decarboxylase | Creatine: sodium symporter activity Glycolipid transporter Glycolipid binding, 3-hydroxyisobutyrate dehydrogenase Leukemia inhibitory factor receptor Superoxide-generating NADPH oxidase Chemokine receptor Interleukin-22 receptor |
8 | DPH vs DNPH1 | MHC class II receptor Gamma-aminobutyric acid: hydrogen symporter chemokine receptor Interleukin-4 receptor Interleukin-7 receptor Arachidonate 5-lipoxygenase Complement receptor | Ammonia ligase Transaldolase 4-alpha-glucanotransferase Choline: sodium symporter Interleukin-8 receptor |
9 | DPH vs DNPH2 | Structural constituent of ribosome MHC class II receptor Ferroxidase NAD(P)H oxidase | 4-alpha-glucanotransferase Phospho-mannomutase Receptor signaling protein tyrosine kinase |