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Table 7 Effect of the CORE andCQR-300 on plasma and urinary malondialdehyde, 5-HT, and plasma creatinine levels

From: The effect of Cissus quadrangularis (CQR-300) and a Cissus formulation (CORE) on obesity and obesity-induced oxidative stress

  Group 1 BMI>30 Placebo (2100 Kcal/day diet) Group 2 BMI>30 CORE (no dietary restriction) Group 3 BMI>30 CORE (2100 Kcal/day diet) Group 4 BMI>30 CQR-300 (2100 Kcal/day diet) Group 5 BMI 24–29.9 CORE (no dietary restriction)
Time (weeks) T = 0 T = 6 T = 0 T = 8 T = 0 T = 8 T = 0 T = 6 T = 0 T = 8
Plasma MDA (μmol/L) 1.8 ± 0.1 1.7 ± 0.1 1.8 ± 0.6 1.0 ± 0.5* 1.9 ± 0.9 1.1 ± 0.6 * 1.6 ± 0.2 1.0 ± 0.4* 1.8 ± 0.3 1.2 ± 0.5*
Urinary MDA (μmol/day) 3476.2 ± 211.7 3492.2 ± 188.4 3864.3 ± 238.4 4325.1 ± 167.5* 4022.1 ± 148.1 4485.8 ± 203.3 3416.2 ± 110.9 3581.5 ± 200.2 3593.8 ± 116.5 3971.0 ± 104.5
Plasma 5-HT (mgl/dl) 30.6 ± 1.9 35.8 ± 2.1 32.5 ± 1.9 42.4 ± 3.4* 38.4 ± 1.5 53.4 ± 3.6 35.4 ± 1.7 54.3 ± 2.9* 33.1 ± 3.7 43.2 ± 2.1*
Plasma creatinine (mg/dl) 25.7 ± 3.8 27.3 ± 1.4 25.9 ± 1.8 31.8 ± 2.1 24.4 ± 3.2 28.9 ± 1.2 27.2 ± 2.2 33.6 ± 1.4* 29.0 ± 0.8 33.8 ± 1.2
  1. Values are means ± SD, comparing starting point to end point, significant differences were at *p < 0.05 for the same treatment.