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Table 7 Effect of the CORE andCQR-300 on plasma and urinary malondialdehyde, 5-HT, and plasma creatinine levels

From: The effect of Cissus quadrangularis (CQR-300) and a Cissus formulation (CORE) on obesity and obesity-induced oxidative stress

 

Group 1

BMI>30

Placebo

(2100 Kcal/day diet)

Group 2

BMI>30

CORE

(no dietary restriction)

Group 3

BMI>30

CORE

(2100 Kcal/day diet)

Group 4

BMI>30

CQR-300

(2100 Kcal/day diet)

Group 5

BMI 24–29.9

CORE

(no dietary restriction)

Time (weeks)

T = 0

T = 6

T = 0

T = 8

T = 0

T = 8

T = 0

T = 6

T = 0

T = 8

Plasma MDA (μmol/L)

1.8 ± 0.1

1.7 ± 0.1

1.8 ± 0.6

1.0 ± 0.5*

1.9 ± 0.9

1.1 ± 0.6 *†

1.6 ± 0.2

1.0 ± 0.4*

1.8 ± 0.3

1.2 ± 0.5*

Urinary MDA (μmol/day)

3476.2 ± 211.7

3492.2 ± 188.4

3864.3 ± 238.4

4325.1 ± 167.5*

4022.1 ± 148.1

4485.8 ± 203.3

3416.2 ± 110.9

3581.5 ± 200.2

3593.8 ± 116.5

3971.0 ± 104.5

Plasma 5-HT (mgl/dl)

30.6 ± 1.9

35.8 ± 2.1

32.5 ± 1.9

42.4 ± 3.4*

38.4 ± 1.5

53.4 ± 3.6†

35.4 ± 1.7

54.3 ± 2.9*

33.1 ± 3.7

43.2 ± 2.1*

Plasma creatinine (mg/dl)

25.7 ± 3.8

27.3 ± 1.4

25.9 ± 1.8

31.8 ± 2.1

24.4 ± 3.2

28.9 ± 1.2

27.2 ± 2.2

33.6 ± 1.4*

29.0 ± 0.8

33.8 ± 1.2

  1. Values are means ± SD, comparing starting point to end point, significant differences were at *p < 0.05 for the same treatment.
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Lipids in Health and Disease

ISSN: 1476-511X