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Table 1 Baseline attributes of study subjects

From: Genetic determinants of statin intolerance

  statin-intolerant controls P-value
Number 133 158  
percent female 36.6% 35.5% NS
age (years) 57.1 ± 12.1 55.9 ± 11.3 NS
current smoking 20.3% 21.8% NS
on treatment for diabetes 24.3% 19.7% NS
on treatment for hypertension 43.7% 39.2% NS
on treatment for hypothyroidism 13.2% 11.5% NS
serum thyrotropin (U/L) 4.4 ± 17.3 2.4 ± 2.7 NS
serum C-reactive protein (mg/dL) 5.0 ± 4.6 4.8 ± 5.7 NS
serum creatine kinase (U/L)    
   - highest recorded on treatment 621 ± 927 280 ± 426 <0.0001
   - lowest recorded off treatment 175 ± 220 120 ± 120 0.0095
   - elevated 5× upper normal limit 17.7% 2.5% <0.0001
   - elevated 10× upper normal limit 5.9% 0.6% 0.009
serum asparagine transaminase (U/L)    
   - highest recorded on treatment 47.5 ± 32.1 40.9 ± 17.5 0.03
   - lowest recorded off treatment 23.8 ± 8.7 23.5 ± 10.6 NS
   - elevated 3× upper normal limit 2.9% 0% 0.03
serum alanine transfaminase (U/L)    
   - highest recorded on treatment 41.9 ± 26.7 38.1 ± 20.7 NS
   - lowest recorded off treatment 32.3 ± 24.5 27.9 ± 15.4 NS
   - elevated 3× upper normal limit 1.5% 0% NS
hospitalized with rhabdomyolysis 1.5% 0% <0.0001