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Table 3 Effects of the chamiloflan on the ceramide content in the liver of the normal and CCl4-treated rats.

From: Effects of flavonoids on sphingolipid turnover in the toxin-damaged liver and liver cells

Animals Ceramide Ceramide/SM
Un-treated 6.74 ± 0.54 0.131 ± 0.010
Control (1) 6.95 ± 0.45 0.121 ± 0.015
Chamiloflan-treated 6.83 ± 0.23 0.112 ± 0.005
Control (2) 5.67 ± 0.46 0.117 ± 0.010
CCl4-treated 7.34 ± 0.47 * 0.162 ± 0.013 *
Chamiloflan + CCl4-treated 5.93 ± 0.51 0.135 ± 0.017
  1. The rats were fed by the chamiloflan (160 mg/kg body weight) or ethanol (1 %, 5 ml/kg body weight) (control 1 group) intragastrically daily for 6 days. The CCl4 (50 % in corn oil, 4 ml/kg body weight) was injected subcutaneously daily for 4 days. Some of the CCl4- treated rats were fed by the chamiloflan (160 mg/kg body weight) daily for 6 days intragastrically. Control (2) rats were injected subcutaneously by the corn oil (2 ml/kg body weight) daily for 4 days and fed by the ethanol (1 %, 5 ml/kg body weight) daily for 6 days. The animals were starved overnight prior the experiments. The amount of the ceramides in the liver homogenate was represented as nmol per mg of protein. Results are mean ± SE of 10 experiments performed in duplicate. * R < 0.05, CCl4-treated rats vs. control.