Scheme showing the metabolism of essential fatty acids. Red line indicates initiation and/or progression of disease. Green line indicates protection from disease and better prognosis. Double arrow indicates feedback regulation that could be both positive and negative. Leukocytes, macrophages, lymphocytes, and myocardial cells produce various PGs, LTs, TXs, cytokines, MPO, and other pro-inflammatory molecules that participate in the pathogenesis of CHD. Leukocytes, macrophages, lymphocytes, myocardial cells also produce lipoxins, resolvins, NPD1, and nitrolipids that have cardioprotective action and enhance healing and prevent or arrest atherosclerosis. Hence, measuring these cardiotoxic and cardioprotective molecules may help in the prediction and prognosis of CHD, and response to therapy.