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Table 2 Fasting PCSK9 and lipid levels pre- and post-atorvastatin treatment

From: Plasma PCSK9 levels are significantly modified by statins and fibrates in humans

 

Baseline

Treatment

% Change

PCSK9 (μg/mL)

5.88 ± 1.70

6.32 ± 2.29*

7.40 ± 25.3

Total cholesterol

5.82 ± 0.76

4.37 ± 0.62***

-25.0 ± 9.06

Triglycerides

1.50 ± 0.56

1.26 ± 0.58**

-16.2 ± 28.0

HDL cholesterol

1.32 ± 0.26

1.43 ± 0.30***

8.03 ± 13.2

LDL cholesterol

3.82 ± 0.67

2.37 ± 0.53***

-38.0 ± 10.3

TC/HDLC Ratio

4.53 ± 0.89

3.17 ± 0.63***

-30.1 ± 9.79

  1. Significance comparing baseline and treatment by Wilcoxon's signed rank test (n = 40). Values expressed as μmol/L except where indicated.
  2. *p < 0.05, **p < 0.001, ***p < 0.0001