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Table 3 Biochemical variables of the ROH-RBP4-TTR complex in plasma of CLD patients classified for individual liver diseases.

From: Isoforms of Retinol binding protein 4 (RBP4) are increased in chronic diseases of the kidney but not of the liver

  Fibrosis1 (n = 38) HCC2 (n = 10) Cirrhosis (n = 7)
ROH (μmoL/L) 1.15 (0.87 – 1.40) 0.68 (0.55 – 0.85) * 0.51 (0.38 – 0.72) *
RBP4 (μmoL/L) 0.98 (0.64 – 1.36) 1.02 (0.76 – 1.02) 0.53 (0.41 – 0.82) *
TTR (μmoL/L) 1.44 (1.86 – 3.09) 1.02 (0.91 – 1.26) 1.00 (0.93 – 1.40)
RBP4/ROH ratio 3 0.97 (0.83 – 2.17) 1.53 (1.00 – 2.13) 1.07 (0.97 – 1.26) *
RBP4/TTR ratio 4 0.71(0.38 – 1.13) 1.05 (0.55 – 1.36) 0.51 (0.41 – 0.61) #
RBP4-L (%)5 33.00 (17.00 – 46.00) 31.00 (16.50 – 56.00) 44.00 (20.00 – 58.00)
RBP4-LL (%) 5 0.00 (0.00 – 6.00) 6.00 (0.00 – 8.00) 0.0 (0.0 – 0.0)
  1. Data are expressed as median with 25th and 75th percentiles.
  2. 1 Fibrosis stage 0–4, 2 HCC = Hepato-cellular carcinoma;
  3. 3 The RBP4/ROH ratio is the molar ratio of serum RBP4 to serum ROH.
  4. 4 The RBP4/TTR ratio is the molar ratio of serum RBP4 to serum TTR.
  5. 5 The intensity of the non-truncated RBP4 (nRBP4) was set 100% and intensities of RBP4-L and RBP4-LL were expressed in % of nRBP4.
  6. * = significantly different from Fibrosis patients < (p < 0.05). # = significantly different from HCC patients (p < 0.05).