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Table 2 Findings of linkage analysis.

From: Genetic studies on the APOA1-C3-A5 gene cluster in Asian Indians with premature coronary artery disease

Analysis Method Whole data
(ASPs = 190)
Subset Data (Positive LOD score families) (ASPs = 77)
   Sac1 LOD score
( P value)
-75G>A +83C>T
Multipoint Linkage analysis NS 7.42 (<0.001)
Single Point Linkage NS 4.49 (<0.0001) 2.77 (0.0002) NS
IBD Pi
(P value)
NS Pi 0.59 (<0.0001) Pi 0.56 (<0.0001) Pi 0.52 (0.0012)
QTL NS TC 1.42 (0.005)
HDL-c 1.72 (0.002)
ApoB 1.19 (0.010)
NS NS
  1. ASPs, Affected sib pairs; IBD, identity by descent; Pi, mean proportion of allele sharing; NS, Not significant, QTL, Quantitative trait loci.