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Table 2 Findings of linkage analysis.

From: Genetic studies on the APOA1-C3-A5 gene cluster in Asian Indians with premature coronary artery disease

Analysis Method

Whole data

(ASPs = 190)

Subset Data (Positive LOD score families) (ASPs = 77)

  

Sac1 LOD score

( P value)

-75G>A

+83C>T

Multipoint Linkage analysis

NS

7.42 (<0.001)

Single Point Linkage

NS

4.49 (<0.0001)

2.77 (0.0002)

NS

IBD Pi

(P value)

NS

Pi 0.59 (<0.0001)

Pi 0.56 (<0.0001)

Pi 0.52 (0.0012)

QTL

NS

TC 1.42 (0.005)

HDL-c 1.72 (0.002)

ApoB 1.19 (0.010)

NS

NS

  1. ASPs, Affected sib pairs; IBD, identity by descent; Pi, mean proportion of allele sharing; NS, Not significant, QTL, Quantitative trait loci.