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Table 4 Cardiopulmonary effects of LCT and MCT/LCT in humans

From: Effects on hemodynamics and gas exchange of omega-3 fatty acid-enriched lipid emulsion in acute respiratory distress syndrome (ARDS): a prospective, randomized, double-blind, parallel group study

A (LCT)
Author Emulsion Infusion rate Patients Results
Venus[11] 20% LCT 100 g/10 h Sepsis
Non-sepsis
↑ MPAP, ↑ Qs/Qt
Venus[12] 20% LCT 100 g/8 h ARDS ↓ PaO2/FiO2
↑ MPAP, ↑ Qs/Qt, ↑ PVR
Hwang[8] 10% LCT 50 g/4 h Healthy
ARDS
Pneumonia
COPD
↓ Qs/Qt, ↑ PaO2/FiO2
↑ Qs/Qt, ↓ PaO2/FiO2
No changes
No changes
Mathru[7] 20% LCT 100 g/10 h
100 g/5 h
ARDS
ARDS
↑ Qs/Qt, =MPAP
=Qs/Qt, ↑ MPAP
B (MCT/LCT)
Radermacher[13] 20% MCT/LCT 50 g/4 h Sepsis No changes
Fiaccadori[14] 20% MCT/LCT 3.3 mg/kg min Heart surgery No changes
Masclans[17] 20% LCT
20% MCT/LCT
2 mg/kg/min 12 h
2 mg/kg/min 12 h
ARDS
ARDS
↑ CO
No changes
Smyrniotis[18] 20% LCT
20% MCT/LCT
50% non-prot cal Pancreatitis with ARDS ↑ MPAP, ↑ Qs/Qt, and ↓ PaO2/FiO2
↑ VO2, ↑ CO
Chassard[19] 20% LCT
20% MCT/LCT
3 mg/kg/min 8 h
3 mg/Kg/min 8 h
Sepsis No changes
↑ VO2
Faucher[20] 20% LCT
20% MCT/LCT
1 ml/kg/h 6 h
1 ml/kg/h 6 h
ARDS ↑ PaO2/FiO2, ↑ DO2
Lekka[16] 20% MCT/LCT
Placebo
  ARDS: lipids
Placebo
↓ PaO2/FiO2, ↓ Comp, ↓ PVR
  1. VO2: oxygen consumption, Comp: compliance.