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Table 1 Gene expression in CD14+ monocytes following treatment with CLA for 3 daysa

From: Effects of 9cis,11trans and 10trans,12cis CLA on osteoclast formation and activity from human CD14+ monocytes

 

Cathepsin K

RANK

MMP-9

TNF-α

9cis,11trans CLA (μM)

    

0

1.00a

1.00a

1.00a

1.00a

6.25

0.88 ± 0.15ab

0.72 ± 0.04ab

1.15 ± 0.17a

1.08 ± 0.07a

12.5

0.59 ± 0.08bc

0.50 ± 0.16b

0.85 ± 0.16a

1.14 ± 0.16a

25

0.44 ± 0.03c

0.50 ± 0.05c

1.00 ± 0.07a

0.99 ± 0.17a

50

0.43 ± 0.05c

0.14 ± 0.05c

0.82 ± 0.10a

0.91 ± 0.10a

10trans,12cis CLA (μM)

    

0

1.00a

1.00a

1.00abc

1.00abc

6.25

0.80 ± 0.09a

0.66 ± 0.07b

1.22 ± 0.06b

1.19 ± 0.08abc

12.5

0.55 ± 0.06b

0.60 ± 0.12bc

0.88 ± 0.10c

1.40 ± 0.19b

25

0.53 ± 0.09b

0.55 ± 0.09bc

0.86 ± 0.07c

0.96 ± 0.09abc

50

0.47 ± 0.14b

0.37 ± 0.02bc

0.66 ± 0.08c

0.85 ± 0.09c

  1. aValues represent the mean ± SEM (n ≥ 3), expressed as relative arbitrary units (R.A.U.) for mRNA expression, determined by real-time RT-PCR. Values with different letters represent significant differences within isomer treatment at P < 0.05.