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Table 1 Gene expression in CD14+ monocytes following treatment with CLA for 3 daysa

From: Effects of 9cis,11trans and 10trans,12cis CLA on osteoclast formation and activity from human CD14+ monocytes

  Cathepsin K RANK MMP-9 TNF-α
9cis,11trans CLA (μM)     
0 1.00a 1.00a 1.00a 1.00a
6.25 0.88 ± 0.15ab 0.72 ± 0.04ab 1.15 ± 0.17a 1.08 ± 0.07a
12.5 0.59 ± 0.08bc 0.50 ± 0.16b 0.85 ± 0.16a 1.14 ± 0.16a
25 0.44 ± 0.03c 0.50 ± 0.05c 1.00 ± 0.07a 0.99 ± 0.17a
50 0.43 ± 0.05c 0.14 ± 0.05c 0.82 ± 0.10a 0.91 ± 0.10a
10trans,12cis CLA (μM)     
0 1.00a 1.00a 1.00abc 1.00abc
6.25 0.80 ± 0.09a 0.66 ± 0.07b 1.22 ± 0.06b 1.19 ± 0.08abc
12.5 0.55 ± 0.06b 0.60 ± 0.12bc 0.88 ± 0.10c 1.40 ± 0.19b
25 0.53 ± 0.09b 0.55 ± 0.09bc 0.86 ± 0.07c 0.96 ± 0.09abc
50 0.47 ± 0.14b 0.37 ± 0.02bc 0.66 ± 0.08c 0.85 ± 0.09c
  1. aValues represent the mean ± SEM (n ≥ 3), expressed as relative arbitrary units (R.A.U.) for mRNA expression, determined by real-time RT-PCR. Values with different letters represent significant differences within isomer treatment at P < 0.05.