Skip to main content
Figure 2 | Lipids in Health and Disease

Figure 2

From: Modulation Peroxisome Proliferators Activated Receptor alpha (PPAR α) and Acyl Coenzyme A: Cholesterol Acyltransferase1 (ACAT1) Gene expression by Fatty Acids in Foam cell

Figure 2

Fatty acids decreases Intracellular total cholesterol (TC), free cholesterol (FC) and esterified cholesterol (EC) levels in THP-1 derived foam cells. THP-1 derived macrophages were cholesterol-loaded with Ac-LDL (50 μg/mL) for 48 hours. Wy14643 (50 μmol/L) and Sandoz58-035 (5 μM) was added 24 hours before cholesterol-loading and thereafter every 24 hours. TC and FC were enzymatically determined and CE were calculated as the difference between TC and FC. Results are the mean ± SD of triplicate determinations, representative of 3 independent experiments. Statistically significant differences between treatments are indicated by one-way ANOVA followed by Tukey multicomparison test. Compared with controls all treatments were significant (p ≤ 0.05).

Back to article page

Lipids in Health and Disease

ISSN: 1476-511X